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The effect of magnesium supplementation on blood pressure: a meta-analysis of randomized clinical trials.

Authors
 Sun Ha Jee  ;  Edgar R. Miller III  ;  Eliseo Guallar  ;  Vikesh K. Singh  ;  Lawrence J. Appel  ;  Michael J. Klag 
Citation
 AMERICAN JOURNAL OF HYPERTENSION, Vol.15(8) : 691-696, 2002 
Journal Title
 AMERICAN JOURNAL OF HYPERTENSION 
ISSN
 0895-7061 
Issue Date
2002
MeSH
Adult ; Aged ; Analysis of Variance ; Blood Pressure/drug effects* ; Confidence Intervals ; Dose-Response Relationship, Drug ; Double-Blind Method ; Female ; Humans ; Hypertension/prevention & control* ; Magnesium/administration & dosage* ; Male ; Middle Aged ; Randomized Controlled Trials as Topic
Keywords
Meta-analysis ; magnesium supplements ; blood pressure
Abstract
An increased intake of magnesium might lower blood pressure (BP), yet evidence from clinical trials is inconsistent, perhaps as a result of small sample size or heterogeneity in study design. We performed a meta-analysis of randomized trials that tested the effects of magnesium supplementation on BP. Twenty trials meeting the inclusion criteria were identified. Random effects models and meta-regression methods were used to pool study results and to determine the dose-response relationship of magnesium to BP. The 20 studies included 14 of hypertensive and 6 of normotensive persons totaling 1220 participants. The doses of magnesium ranged from 10 to 40 mmol/day (median, 15.4 mmol/day). Magnesium supplementation resulted in only a small overall reduction in BP. The pooled net estimates of BP change (95% confidence interval [CI]) were -0.6 (-2.2 to 1.0) mm Hg for systolic BP and -0.8 (-1.9 to 0.4) mm Hg for diastolic BP. However, there was an apparent dose-dependent effect of magnesium, with reductions of 4.3 mm Hg systolic BP (95% CI 6.3 to 2.2; P < .001) and of 2.3 mm Hg diastolic BP (95% CI 4.9 to 0.0; P = .09) for each 10 mmol/day increase in magnesium dose. Our meta-analysis detected dose-dependent BP reductions from magnesium supplementation. However, adequately powered trials with sufficiently high doses of magnesium supplements need to be performed to confirm this relationship.
Full Text
http://search.proquest.com/docview/1026586860/abstract?accountid=15179
DOI
10.1016/S0895-7061(02)02964-3
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/144118
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