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The effect of magnesium supplementation on blood pressure: a meta-analysis of randomized clinical trials.

DC FieldValueLanguage
dc.contributor.author지선하-
dc.date.accessioned2016-05-16T11:14:46Z-
dc.date.available2016-05-16T11:14:46Z-
dc.date.issued2002-
dc.identifier.issn0895-7061-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/144118-
dc.description.abstractAn increased intake of magnesium might lower blood pressure (BP), yet evidence from clinical trials is inconsistent, perhaps as a result of small sample size or heterogeneity in study design. We performed a meta-analysis of randomized trials that tested the effects of magnesium supplementation on BP. Twenty trials meeting the inclusion criteria were identified. Random effects models and meta-regression methods were used to pool study results and to determine the dose-response relationship of magnesium to BP. The 20 studies included 14 of hypertensive and 6 of normotensive persons totaling 1220 participants. The doses of magnesium ranged from 10 to 40 mmol/day (median, 15.4 mmol/day). Magnesium supplementation resulted in only a small overall reduction in BP. The pooled net estimates of BP change (95% confidence interval [CI]) were -0.6 (-2.2 to 1.0) mm Hg for systolic BP and -0.8 (-1.9 to 0.4) mm Hg for diastolic BP. However, there was an apparent dose-dependent effect of magnesium, with reductions of 4.3 mm Hg systolic BP (95% CI 6.3 to 2.2; P < .001) and of 2.3 mm Hg diastolic BP (95% CI 4.9 to 0.0; P = .09) for each 10 mmol/day increase in magnesium dose. Our meta-analysis detected dose-dependent BP reductions from magnesium supplementation. However, adequately powered trials with sufficiently high doses of magnesium supplements need to be performed to confirm this relationship.-
dc.description.statementOfResponsibilityopen-
dc.format.extent691~696-
dc.relation.isPartOfAMERICAN JOURNAL OF HYPERTENSION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAnalysis of Variance-
dc.subject.MESHBlood Pressure/drug effects*-
dc.subject.MESHConfidence Intervals-
dc.subject.MESHDose-Response Relationship, Drug-
dc.subject.MESHDouble-Blind Method-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHHypertension/prevention & control*-
dc.subject.MESHMagnesium/administration & dosage*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRandomized Controlled Trials as Topic-
dc.titleThe effect of magnesium supplementation on blood pressure: a meta-analysis of randomized clinical trials.-
dc.typeArticle-
dc.contributor.collegeGraduate School of Public Health (보건대학원)-
dc.contributor.departmentGraduate School of Public Health (보건대학원)-
dc.contributor.googleauthorSun Ha Jee-
dc.contributor.googleauthorEdgar R. Miller III-
dc.contributor.googleauthorEliseo Guallar-
dc.contributor.googleauthorVikesh K. Singh-
dc.contributor.googleauthorLawrence J. Appel-
dc.contributor.googleauthorMichael J. Klag-
dc.identifier.doi10.1016/S0895-7061(02)02964-3-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03965-
dc.relation.journalcodeJ00087-
dc.identifier.eissn1941-7225-
dc.identifier.pmid12160191-
dc.identifier.urlhttp://search.proquest.com/docview/1026586860/abstract?accountid=15179-
dc.subject.keywordMeta-analysis-
dc.subject.keywordmagnesium supplements-
dc.subject.keywordblood pressure-
dc.contributor.alternativeNameJee, Sun Ha-
dc.contributor.affiliatedAuthorJee, Sun Ha-
dc.rights.accessRightsnot free-
dc.citation.volume15-
dc.citation.number8-
dc.citation.startPage691-
dc.citation.endPage696-
dc.identifier.bibliographicCitationAMERICAN JOURNAL OF HYPERTENSION, Vol.15(8) : 691-696, 2002-
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers

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