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Mercury distribution and concentration in rats fed powered dental amalgam.

Authors
 Keun Bae Song  ;  Young Eun Lee  ;  Seong Hwa Jeong  ;  Hye Young Kim  ;  Ho Keun Kwon 
Citation
 ARCHIVES OF ORAL BIOLOGY, Vol.47(4) : 307-313, 2002 
Journal Title
ARCHIVES OF ORAL BIOLOGY
ISSN
 0003-9969 
Issue Date
2002
MeSH
Animal Feed ; Animals ; Body Burden ; Brain/metabolism ; Dental Amalgam ; Female ; Kidney Cortex/metabolism ; Liver/metabolism ; Mercury/pharmacokinetics* ; Rats ; Rats, Sprague-Dawley ; Tissue Distribution
Keywords
Mercury ; Powdered dental amalgam ; Autometallography ; Cold-vapour atomic absorption spectrometry
Abstract
The aim was to evaluate the distribution and elimination of mercury in the tissues of rats exposed to powdered dental amalgam. The study comprised of three groups: the first (A) was an unexposed control, the second (B) was fed 8.3 mg of powdered amalgam weekly for 12 weeks, and the third (C) was fed 25.0 mg of powdered amalgam weekly for 4 weeks followed by either a 4- or 8-week period of non-exposure. The total amount of amalgam administered in each of the latter two groups was 0.1 g. Animals were killed at 4, 8 and 12 weeks, and their kidneys, liver and brains were removed. Mercury present in tissues from one side was analysed by cold-vapour atomic absorption spectrometry; tissues from the other side were stained autometallographically. No mercury was detected in any tissue of control group A. In group B, the mercury concentration in the kidneys was significantly higher than that of the control, whereas in group C, the mercury concentration in both the liver and kidneys decreased significantly during the period of non-exposure. Mercury was not detected in brain tissue from any group. The light-microscopic findings were in agreement with the quantitative results. Mercury grains were most common in the renal cortex, especially in the proximal tubule. Although there was some mercury accumulation in the tissues of the two experimental groups, no pathological reactions were noted. These data suggest that, in the rat, the ingestion of dental amalgam in small quantities for a limited period does not lead to morphological changes in the liver, brain or kidneys. It seems likely that mercury does not accumulate in brain tissue and that any accumulation in the kidneys and liver is at least partially reduced after ingestion ceases.
Full Text
http://www.sciencedirect.com/science/article/pii/S000399690200002X
DOI
10.1016/S0003-9969(02)00002-X
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Preventive Dentistry and Public Oral Health (예방치과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Ho Keun(권호근)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/144106
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