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Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells

 Yang D. Teng  ;  Erin B. Lavik  ;  Xianlu Qu  ;  Kook I. Park  ;  Jitka Ourednik  ;  David Zurakowski  ;  Robert Langer  ;  Evan Y. Snyder 
 Proceedings of the National Academy of Sciences of the United States of America, Vol.99(5) : 3024-3029, 2002 
Journal Title
 Proceedings of the National Academy of Sciences of the United States of America 
Issue Date
Animals ; Astrocytes/chemistry ; Astrocytes/physiology ; Female ; GAP-43 Protein/analysis ; Glial Fibrillary Acidic Protein/analysis ; Mice ; Nerve Fibers/chemistry ; Nerve Fibers/physiology ; Nerve Regeneration/physiology ; Neurofilament Proteins/analysis ; Neurons/chemistry ; Neurons/physiology ; Neurons/transplantation* ; Polymers ; Rats ; Rats, Sprague-Dawley ; Spinal Cord Injuries/metabolism ; Spinal Cord Injuries/physiopathology ; Spinal Cord Injuries/therapy* ; Stem Cell Transplantation* ; Stem Cells/chemistry ; Stem Cells/physiology ; Thoracic Vertebrae/injuries ; Wounds and Injuries
To better direct repair following spinal cord injury (SCI), we designed an implant modeled after the intact spinal cord consisting of a multicomponent polymer scaffold seeded with neural stem cells. Implantation of the scaffold–neural stem cells unit into an adult rat hemisection model of SCI promoted long-term improvement in function (persistent for 1 year in some animals) relative to a lesion-control group. At 70 days postinjury, animals implanted with scaffold-plus-cells exhibited coordinated, weight-bearing hindlimb stepping. Histology and immunocytochemical analysis suggested that this recovery might be attributable partly to a reduction in tissue loss from secondary injury processes as well as in diminished glial scarring. Tract tracing demonstrated corticospinal tract fibers passing through the injury epicenter to the caudal cord, a phenomenon not present in untreated groups. Together with evidence of enhanced local GAP-43 expression not seen in controls, these findings suggest a possible regeneration component. These results may suggest a new approach to SCI and, more broadly, may serve as a prototype for multidisciplinary strategies against complex neurological problems.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Park, Kook In(박국인) ORCID logo https://orcid.org/0000-0001-8499-9293
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