Cited 865 times in
Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박국인 | - |
dc.date.accessioned | 2016-05-16T11:13:40Z | - |
dc.date.available | 2016-05-16T11:13:40Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/144077 | - |
dc.description.abstract | To better direct repair following spinal cord injury (SCI), we designed an implant modeled after the intact spinal cord consisting of a multicomponent polymer scaffold seeded with neural stem cells. Implantation of the scaffold–neural stem cells unit into an adult rat hemisection model of SCI promoted long-term improvement in function (persistent for 1 year in some animals) relative to a lesion-control group. At 70 days postinjury, animals implanted with scaffold-plus-cells exhibited coordinated, weight-bearing hindlimb stepping. Histology and immunocytochemical analysis suggested that this recovery might be attributable partly to a reduction in tissue loss from secondary injury processes as well as in diminished glial scarring. Tract tracing demonstrated corticospinal tract fibers passing through the injury epicenter to the caudal cord, a phenomenon not present in untreated groups. Together with evidence of enhanced local GAP-43 expression not seen in controls, these findings suggest a possible regeneration component. These results may suggest a new approach to SCI and, more broadly, may serve as a prototype for multidisciplinary strategies against complex neurological problems. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 3024~3029 | - |
dc.relation.isPartOf | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Astrocytes/chemistry | - |
dc.subject.MESH | Astrocytes/physiology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | GAP-43 Protein/analysis | - |
dc.subject.MESH | Glial Fibrillary Acidic Protein/analysis | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Nerve Fibers/chemistry | - |
dc.subject.MESH | Nerve Fibers/physiology | - |
dc.subject.MESH | Nerve Regeneration/physiology | - |
dc.subject.MESH | Neurofilament Proteins/analysis | - |
dc.subject.MESH | Neurons/chemistry | - |
dc.subject.MESH | Neurons/physiology | - |
dc.subject.MESH | Neurons/transplantation* | - |
dc.subject.MESH | Polymers | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Spinal Cord Injuries/metabolism | - |
dc.subject.MESH | Spinal Cord Injuries/physiopathology | - |
dc.subject.MESH | Spinal Cord Injuries/therapy* | - |
dc.subject.MESH | Stem Cell Transplantation* | - |
dc.subject.MESH | Stem Cells/chemistry | - |
dc.subject.MESH | Stem Cells/physiology | - |
dc.subject.MESH | Thoracic Vertebrae/injuries | - |
dc.subject.MESH | Wounds and Injuries | - |
dc.title | Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | Yang D. Teng | - |
dc.contributor.googleauthor | Erin B. Lavik | - |
dc.contributor.googleauthor | Xianlu Qu | - |
dc.contributor.googleauthor | Kook I. Park | - |
dc.contributor.googleauthor | Jitka Ourednik | - |
dc.contributor.googleauthor | David Zurakowski | - |
dc.contributor.googleauthor | Robert Langer | - |
dc.contributor.googleauthor | Evan Y. Snyder | - |
dc.identifier.doi | 10.1073/pnas.052678899 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01438 | - |
dc.relation.journalcode | J02550 | - |
dc.identifier.eissn | 1091-6490 | - |
dc.identifier.pmid | 11867737 | - |
dc.contributor.alternativeName | Park, Kook In | - |
dc.contributor.affiliatedAuthor | Park, Kook In | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 99 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 3024 | - |
dc.citation.endPage | 3029 | - |
dc.identifier.bibliographicCitation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol.99(5) : 3024-3029, 2002 | - |
dc.identifier.rimsid | 55569 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.