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Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells

DC FieldValueLanguage
dc.contributor.author박국인-
dc.date.accessioned2016-05-16T11:13:40Z-
dc.date.available2016-05-16T11:13:40Z-
dc.date.issued2002-
dc.identifier.issn0027-8424-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/144077-
dc.description.abstractTo better direct repair following spinal cord injury (SCI), we designed an implant modeled after the intact spinal cord consisting of a multicomponent polymer scaffold seeded with neural stem cells. Implantation of the scaffold–neural stem cells unit into an adult rat hemisection model of SCI promoted long-term improvement in function (persistent for 1 year in some animals) relative to a lesion-control group. At 70 days postinjury, animals implanted with scaffold-plus-cells exhibited coordinated, weight-bearing hindlimb stepping. Histology and immunocytochemical analysis suggested that this recovery might be attributable partly to a reduction in tissue loss from secondary injury processes as well as in diminished glial scarring. Tract tracing demonstrated corticospinal tract fibers passing through the injury epicenter to the caudal cord, a phenomenon not present in untreated groups. Together with evidence of enhanced local GAP-43 expression not seen in controls, these findings suggest a possible regeneration component. These results may suggest a new approach to SCI and, more broadly, may serve as a prototype for multidisciplinary strategies against complex neurological problems.-
dc.description.statementOfResponsibilityopen-
dc.format.extent3024~3029-
dc.relation.isPartOfPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHAstrocytes/chemistry-
dc.subject.MESHAstrocytes/physiology-
dc.subject.MESHFemale-
dc.subject.MESHGAP-43 Protein/analysis-
dc.subject.MESHGlial Fibrillary Acidic Protein/analysis-
dc.subject.MESHMice-
dc.subject.MESHNerve Fibers/chemistry-
dc.subject.MESHNerve Fibers/physiology-
dc.subject.MESHNerve Regeneration/physiology-
dc.subject.MESHNeurofilament Proteins/analysis-
dc.subject.MESHNeurons/chemistry-
dc.subject.MESHNeurons/physiology-
dc.subject.MESHNeurons/transplantation*-
dc.subject.MESHPolymers-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHSpinal Cord Injuries/metabolism-
dc.subject.MESHSpinal Cord Injuries/physiopathology-
dc.subject.MESHSpinal Cord Injuries/therapy*-
dc.subject.MESHStem Cell Transplantation*-
dc.subject.MESHStem Cells/chemistry-
dc.subject.MESHStem Cells/physiology-
dc.subject.MESHThoracic Vertebrae/injuries-
dc.subject.MESHWounds and Injuries-
dc.titleFunctional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthorYang D. Teng-
dc.contributor.googleauthorErin B. Lavik-
dc.contributor.googleauthorXianlu Qu-
dc.contributor.googleauthorKook I. Park-
dc.contributor.googleauthorJitka Ourednik-
dc.contributor.googleauthorDavid Zurakowski-
dc.contributor.googleauthorRobert Langer-
dc.contributor.googleauthorEvan Y. Snyder-
dc.identifier.doi10.1073/pnas.052678899-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01438-
dc.relation.journalcodeJ02550-
dc.identifier.eissn1091-6490-
dc.identifier.pmid11867737-
dc.contributor.alternativeNamePark, Kook In-
dc.contributor.affiliatedAuthorPark, Kook In-
dc.rights.accessRightsfree-
dc.citation.volume99-
dc.citation.number5-
dc.citation.startPage3024-
dc.citation.endPage3029-
dc.identifier.bibliographicCitationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol.99(5) : 3024-3029, 2002-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers

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