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방광암 환자에서 방광내 BCG 점적술 시행 후 발생한 육아종성 간염 1 예

Other Titles
 Case Reports : A Case of Granulomatous Hepatitis Developed after Intravesical BCG Instillation for Bladder Cancer 
 손주익  ;  정준표  ;  백승석  ;  이정일  ;  김정환  ;  문병수  ;  이관식  ;  이상인  ;  문영명  ;  박찬일  ;  김혜령  ;  정병하 
 Korean Journal of Gastroenterology, Vol.39(5) : 375-378, 2002 
Journal Title
 Korean Journal of Gastroenterology (대한소화기학회지) 
Issue Date
Granulomatous hepatitis ; BCG ; Bladder cancer
Granulomatous hepatitis is a rare but serious systemic complication of intravesical Bacillus Calmette- Guerin (BCG) therapy, which has been proved more effective than most chemotherapeutic agents in the treatment of superficial bladder tumors and carcinoma in situ. Recently, we experienced a 64 year-old male with granulomatous hepatitis which had occurred following an intravesical BCG immunotherapy for an adjuvant treatment of superficial bladder cancer. The patient took isoniazid (300 mg) due to fever that had developed soon after an intravesical BCG immunotherapy. When he presented with clinical features of hepatic failure and sepsis, it was difficult to differentiate granulomatous hepatitis from isoniazid- induced hepatotoxicity. The patient died 20 days after the intravesical BCG immunotherapy (2 days after liver biopsy). This case indicates that granulomatous hepatitis is a fatal complication of the intravesical BCG therapy. Thus, a close follow- up and prompt diagnostic effort with optimal treatment should be instituted.
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1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Chan Il(박찬일)
Lee, Kwan Sik(이관식) ORCID logo https://orcid.org/0000-0002-3672-1198
Chung, Byung Ha(정병하) ORCID logo https://orcid.org/0000-0001-9817-3660
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