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An estrogen receptor (ER) alpha DNA-binding domain knock-in mutation provides evidence for nonclassical ER pathway signaling in vivo

Authors
 Monika Jakacka  ;  Masafumi Ito  ;  Fred Martinson  ;  Toshio Ishikawa  ;  Eun Jig Lee  ;  J. Larry Jameson 
Citation
 MOLECULAR ENDOCRINOLOGY , Vol.16(10) : 2188-2201, 2002 
Journal Title
 MOLECULAR ENDOCRINOLOGY 
ISSN
 0888-8809 
Issue Date
2002
Abstract
We created a nonclassical estrogen receptor (ER) knock-in mouse model by introducing a mutation that selectively eliminates classical ER signaling through estrogen response elements, while preserving the nonclassical ER pathway. Heterozygous nonclassical ER knock-in (NERKI) females are infertile. Their ovaries contain no corpora lutea, reflecting a defect in ovulation, and the stromal cells contain lipid droplets, suggesting altered steroidogenesis. The uteri are enlarged with evidence of cystic endometrial hyperplasia, and the mammary glands are hypoplastic. These phenotypic features indicate differential ER effects on growth and development in various estrogen-responsive tissues. These findings suggest that nonclassical ER signaling pathways play an important physiological role in the development and function of the reproductive system.
Full Text
http://press.endocrine.org/doi/abs/10.1210/me.2001-0174
DOI
10.1210/me.2001-0174
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Eun Jig(이은직) ORCID logo https://orcid.org/0000-0002-9876-8370
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/143883
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