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An estrogen receptor (ER) alpha DNA-binding domain knock-in mutation provides evidence for nonclassical ER pathway signaling in vivo

DC FieldValueLanguage
dc.contributor.author이은직-
dc.date.accessioned2016-05-16T11:08:35Z-
dc.date.available2016-05-16T11:08:35Z-
dc.date.issued2002-
dc.identifier.issn0888-8809-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/143883-
dc.description.abstractWe created a nonclassical estrogen receptor (ER) knock-in mouse model by introducing a mutation that selectively eliminates classical ER signaling through estrogen response elements, while preserving the nonclassical ER pathway. Heterozygous nonclassical ER knock-in (NERKI) females are infertile. Their ovaries contain no corpora lutea, reflecting a defect in ovulation, and the stromal cells contain lipid droplets, suggesting altered steroidogenesis. The uteri are enlarged with evidence of cystic endometrial hyperplasia, and the mammary glands are hypoplastic. These phenotypic features indicate differential ER effects on growth and development in various estrogen-responsive tissues. These findings suggest that nonclassical ER signaling pathways play an important physiological role in the development and function of the reproductive system.-
dc.description.statementOfResponsibilityopen-
dc.format.extent2188~2201-
dc.relation.isPartOfMOLECULAR ENDOCRINOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleAn estrogen receptor (ER) alpha DNA-binding domain knock-in mutation provides evidence for nonclassical ER pathway signaling in vivo-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorMonika Jakacka-
dc.contributor.googleauthorMasafumi Ito-
dc.contributor.googleauthorFred Martinson-
dc.contributor.googleauthorToshio Ishikawa-
dc.contributor.googleauthorEun Jig Lee-
dc.contributor.googleauthorJ. Larry Jameson-
dc.identifier.doi10.1210/me.2001-0174-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03050-
dc.relation.journalcodeJ02257-
dc.identifier.eissn1944-9917-
dc.identifier.urlhttp://press.endocrine.org/doi/abs/10.1210/me.2001-0174-
dc.contributor.alternativeNameLee, Eun Jig-
dc.contributor.affiliatedAuthorLee, Eun Jig-
dc.rights.accessRightsnot free-
dc.citation.volume16-
dc.citation.number10-
dc.citation.startPage2188-
dc.citation.endPage2201-
dc.identifier.bibliographicCitationMOLECULAR ENDOCRINOLOGY , Vol.16(10) : 2188-2201, 2002-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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