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Induction of apoptosis and caspase-3 activation by chemopreventive [6]-paradol and structurally related compounds in KB cells.

Authors
 Young Sam Keuma  ;  Jin Kim  ;  Keun Hyung Lee  ;  Kwang Kyun Park  ;  Young Joon Surh  ;  Jong Min Lee  ;  Sang Sup Lee  ;  Jung Hoon Yoon  ;  So Yeon Joo  ;  In Ho Cha  ;  Jong In Yook 
Citation
 CANCER LETTERS, Vol.177(1) : 41-47, 2002 
Journal Title
 CANCER LETTERS 
ISSN
 0304-3835 
Issue Date
2002
MeSH
Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology* ; Apoptosis/drug effects* ; Blotting, Western ; Carcinoma, Squamous Cell/enzymology* ; Carcinoma, Squamous Cell/prevention & control ; Caspase 3 ; Caspases/metabolism* ; Cell Survival/drug effects ; DNA Fragmentation ; Enzyme Induction ; Flow Cytometry ; Guaiacol/analogs & derivatives* ; Guaiacol/chemistry ; Guaiacol/pharmacology* ; Humans ; Ketones/chemistry ; Ketones/pharmacology* ; Mouth Neoplasms/enzymology* ; Mouth Neoplasms/prevention & control ; Tumor Cells, Cultured/cytology ; Tumor Cells, Cultured/drug effects*
Keywords
[6]-paradol ; Apoptosis ; KB cells ; Caspase-3
Abstract
[6]-paradol, a pungent phenolic substance found in ginger and other Zingiberaceae plants, has been demonstrated to be an effective inhibitor of tumor promotion in mouse skin carcinogenesis. In the present study, we found that [6]-paradol and other structurally related derivatives, [10]-paradol, [3]-dehydroparadol, [6]-dehydroparadol, and [10]-dehydroparadol, with the exception of [3]-paradol induce apoptosis in an oral squamous carcinoma cell line, KB, in a dose-dependent manner. [10]-paradol and [10]-dehydroparadol exhibited a similar extent of cytotoxicity to that of [6]-paradol. [6]-Dehydroparadol and [3]-dehydroparadol appeared to be more potent, with an IC50 less than 40 μM. Treatment of KB cells with an apoptosis-inducing concentration of [6]-dehydroparadol caused induction of proteolytic cleavage of pro-caspase-3. These results suggest that [6]-paradol and structurally related derivatives induce apoptosis through a caspase-3-dependent mechanism.
Full Text
http://www.sciencedirect.com/science/article/pii/S0304383501007819
DOI
10.1016/S0304-3835(01)00781-9
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin(김진)
Park, Kwang Kyun(박광균)
Yook, Jong In(육종인) ORCID logo https://orcid.org/0000-0002-7318-6112
Cha, In Ho(차인호) ORCID logo https://orcid.org/0000-0001-8259-2190
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/143633
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