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Association of G-33A Polymorphism in the Thrombomodulin Gene with Myocardial Infarction in Koreans.

 Hyun Young Park  ;  Toru Nabika  ;  Yangsoo Jang  ;  Hyuck Moon Kwon  ;  Seung Yun Cho  ;  Junichi Masuda 
 HYPERTENSION RESEARCH, Vol.25(3) : 389-394, 2002 
Journal Title
Issue Date
thrombomodulin ; myocardial infarction ; case-control study ; single-nucleotide polymorphism ; genetics
Thrombomodulin (TM), a thrombin receptor expressed on the endothelial surface, is known to play an important role in the anti-thrombogenic system in vivo. In this study, we examined the effects of 3 single-nucleotide polymorphisms (SNPs) in the TM gene (G-33A, C1418T and C1922T) on the development of myocardial infarction (MI) in Koreans. We found that G-33A was a common SNP (the minor allele frequency was 0.09) in Koreans. Eighty-five MI patients who had received coronary angiography were enrolled and were divided into 3 groups according to the number of coronary arteries in which stenosis was found angiographically (1-vessel disease (1VD) to 3-vessel disease (3VD)). The criterion of coronary stenosis was 50% or more stenosis on angiography. In addition, 102 controls (CONT) who had no significant stenosis were employed. The number of AA⁄GA genotypes of G-33A was found to be significantly greater in the 1VD than in the CONT (p =0.004 by Χ2-test) while no significant difference was found between the multivessel disease (2-3VD) and the CONT. Multiple logistic analysis showed that G-33A was an independent risk factor for the 1VD with an odds ratio of 4.63 (95% confidence interval; 1.62-13.3). C1418T and C1922T were both in linkage disequilibrium with G-33A; however, they were not independent risks for either the 1VD or the 2-3VD. A reporter gene assay showed that G-33A had a significant effect on the TM promoter activity. These results indicated that G-33A polymorphism in TM might be a genetic risk factor for myocardial infarction. (Hypertens Res 2002; 25: 389-394)
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Hyuck Moon(권혁문) ORCID logo https://orcid.org/0000-0001-9901-5015
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
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