Cited 24 times in
Association of G-33A Polymorphism in the Thrombomodulin Gene with Myocardial Infarction in Koreans.
DC Field | Value | Language |
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dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2016-05-16T11:01:12Z | - |
dc.date.available | 2016-05-16T11:01:12Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0916-9636 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/143609 | - |
dc.description.abstract | Thrombomodulin (TM), a thrombin receptor expressed on the endothelial surface, is known to play an important role in the anti-thrombogenic system in vivo. In this study, we examined the effects of 3 single-nucleotide polymorphisms (SNPs) in the TM gene (G-33A, C1418T and C1922T) on the development of myocardial infarction (MI) in Koreans. We found that G-33A was a common SNP (the minor allele frequency was 0.09) in Koreans. Eighty-five MI patients who had received coronary angiography were enrolled and were divided into 3 groups according to the number of coronary arteries in which stenosis was found angiographically (1-vessel disease (1VD) to 3-vessel disease (3VD)). The criterion of coronary stenosis was 50% or more stenosis on angiography. In addition, 102 controls (CONT) who had no significant stenosis were employed. The number of AA⁄GA genotypes of G-33A was found to be significantly greater in the 1VD than in the CONT (p =0.004 by Χ2-test) while no significant difference was found between the multivessel disease (2-3VD) and the CONT. Multiple logistic analysis showed that G-33A was an independent risk factor for the 1VD with an odds ratio of 4.63 (95% confidence interval; 1.62-13.3). C1418T and C1922T were both in linkage disequilibrium with G-33A; however, they were not independent risks for either the 1VD or the 2-3VD. A reporter gene assay showed that G-33A had a significant effect on the TM promoter activity. These results indicated that G-33A polymorphism in TM might be a genetic risk factor for myocardial infarction. (Hypertens Res 2002; 25: 389-394) | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 389~394 | - |
dc.relation.isPartOf | HYPERTENSION RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Association of G-33A Polymorphism in the Thrombomodulin Gene with Myocardial Infarction in Koreans. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Hyun Young Park | - |
dc.contributor.googleauthor | Toru Nabika | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Hyuck Moon Kwon | - |
dc.contributor.googleauthor | Seung Yun Cho | - |
dc.contributor.googleauthor | Junichi Masuda | - |
dc.identifier.doi | 10.1291/hypres.25.389 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A00260 | - |
dc.relation.journalcode | J01017 | - |
dc.identifier.eissn | 1348-4214 | - |
dc.subject.keyword | thrombomodulin | - |
dc.subject.keyword | myocardial infarction | - |
dc.subject.keyword | case-control study | - |
dc.subject.keyword | single-nucleotide polymorphism | - |
dc.subject.keyword | genetics | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 25 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 389 | - |
dc.citation.endPage | 394 | - |
dc.identifier.bibliographicCitation | HYPERTENSION RESEARCH, Vol.25(3) : 389-394, 2002 | - |
dc.identifier.rimsid | 38300 | - |
dc.type.rims | ART | - |
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