187 275

Cited 0 times in

Zeste maintains repression of Ubx transgenes: support for a new model of Polycomb repression

 Man Wook Hur  ;  Jeffrey D. Laney  ;  Sang Hack Jeon  ;  Janann Ali  ;  Mark D. Biggin 
 DEVELOPMENT, Vol.129(6) : 1339-1343, 2002 
Journal Title
Issue Date
Animals ; DNA-Binding Proteins/genetics* ; Drosophila/embryology ; Drosophila/genetics* ; Drosophila Proteins/genetics* ; Gene Expression Regulation, Developmental* ; Homeodomain Proteins/genetics ; Insect Proteins/genetics* ; Polycomb Repressive Complex 1 ; Promoter Regions, Genetic/genetics* ; Repressor Proteins/genetics ; Transcription Factors/genetics ; Transcriptional Activation* ; Transfection
Polycomb group ; Trithorax group ; Homeotic ; Zeste ; GAGA ; Drosophila
During late embryogenesis, the expression domains of homeotic genes are maintained by two groups of ubiquitously expressed regulators: the Polycomb repressors and the Trithorax activators. It is not known how the activities of the two maintenance systems are initially targeted to the correct genes. Zeste and GAGA are sequence-specific DNA-binding proteins previously shown to be Trithorax group activators of the homeotic gene Ultrabithorax (Ubx). We demonstrate that Zeste and GAGA DNA-binding sites at the proximal promoter are also required to maintain, but not to initiate, repression of Ubx. Furthermore, the repression mediated by Zeste DNA-binding site is abolished in zeste null embryos. These data imply that Zeste and probably GAGA mediate Polycomb repression. We present a model in which the dual transcriptional activities of Zeste and GAGA are an essential component of the mechanism that chooses which maintenance system is to be targeted to a given promoter.
Files in This Item:
T200203018.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Hur, Man Wook(허만욱) ORCID logo https://orcid.org/0000-0002-3416-1334
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.