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Molecular characterzation of metallo-beta-lacmatase-producing A. baumannii and Acinetobacter genomospecies 3 from korea : identification of two novel

Authors
 Jong Hwa Yum  ;  Keonsoo Yi  ;  Hyukmin Lee  ;  Dongeun Yong  ;  Kyungwon Lee  ;  June Myung Kim  ;  Gian Maria Rossolini  ;  Yunsop Chong 
Citation
 JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, Vol.49(5) : 837-840, 2002 
Journal Title
 JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 
ISSN
 0305-7453 
Issue Date
2002
Abstract
Carbapenem-resistant Acinetobacter spp. used to be rare, but are increasingly isolated in Korea. Among 28 isolates of imipenem-resistant Acinetobacter spp. found in a Korean hospital in 1998 and 1999, 14 produced metallo-b-lactamases. The blaVIM-2 gene was detected, by PCR, in 11 and two isolates of Acinetobacter baumannii and Acinetobacter genomospecies 3, respectively, and blaIMP-1 in one isolate of A. baumannii. The MICs of imipenem for the isolates were 8–32 mg/L. PFGE analysis of SmaI-digested genomic DNA gave identical patterns in eight of 11 blaVIM-2-positive A. baumannii isolates from respiratory specimens of ICU patients. The blaVIM-2 gene cassettes in the isolates are identical to those from Pseudomonas aeruginosa isolates in Europe, but are inserted into new class I integrons In105 and In106. The attC site of the last cassette of the array in In106 is interrupted by the insertion of a putative class II intron. This is the first report of VIM-2 b-lactamase-producing A. baumannii and Acinetobacter genomospecies 3. Production of the VIM-2 enzyme presents an emerging threat of carbapenem resistance among Acinetobacter spp. in Korea.
Files in This Item:
T200202867.pdf Download
DOI
10.1093/jac/dkf043
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Research Institute of Bacterial Resistance (세균내성연구소) > 1. Journal Papers
Yonsei Authors
Kim, June Myung(김준명)
Yum, Jong Hwa(염종화)
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/143513
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