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Assessment of chromosomal losses and gains in hepatocellular carcinoma

Authors
 Joon Chang  ;  Nam Gyun Kim  ;  Zhe Piao  ;  Chanil Park  ;  Kang Sik Park  ;  Young Ki Paik  ;  Woo Jung Lee  ;  Byong Ro Kim  ;  Hoguen Kim 
Citation
 CANCER LETTERS, Vol.182(2) : 193-202, 2002 
Journal Title
 CANCER LETTERS 
ISSN
 0304-3835 
Issue Date
2002
MeSH
Carcinoma, Hepatocellular/genetics* ; Chromosome Deletion* ; Chromosome Mapping* ; Gene Duplication* ; Humans ; Liver Neoplasms/genetics* ; Loss of Heterozygosity* ; Polymerase Chain Reaction/methods
Keywords
Allelic imbalance ; Comparative genomic hybridization ; Hepatocellular carcinomas
Abstract
We examined the chromosomal changes of 22 hepatocellular carcinomas (HCCs) by comparative genomic hybridization (CGH) analysis and compared the results with that of allelotype by polymerase chain reaction based loss of heterozygosity (PCR-LOH) analysis. By CGH analysis, frequent chromosomal losses were noted in the chromosomal region of 4q (59%), 8p (77%), and 16q (50%), whereas gains were noted in 1q (86%) and 8q (77%). All of these chromosomal arms were revealed to have frequent allelic imbalances by PCR-LOH analysis, however, 9% of chromosomal aberrations were detected only by CGH analysis and 2% were detected only by PCR-LOH analysis. Our results suggest that CGH analysis gives more precise results for the screening of chromosomal aberrations in HCCs than that of PCR-LOH analysis with randomly selected microsatellite markers.
Full Text
http://www.sciencedirect.com/science/article/pii/S0304383502000836
DOI
10.1016/S0304-3835(02)00083-6
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hogeun(김호근)
Park, Chan Il(박찬일)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/143475
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