Cited 35 times in
Assessment of chromosomal losses and gains in hepatocellular carcinoma
DC Field | Value | Language |
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dc.contributor.author | 김호근 | - |
dc.contributor.author | 박찬일 | - |
dc.date.accessioned | 2016-05-16T10:57:23Z | - |
dc.date.available | 2016-05-16T10:57:23Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/143475 | - |
dc.description.abstract | We examined the chromosomal changes of 22 hepatocellular carcinomas (HCCs) by comparative genomic hybridization (CGH) analysis and compared the results with that of allelotype by polymerase chain reaction based loss of heterozygosity (PCR-LOH) analysis. By CGH analysis, frequent chromosomal losses were noted in the chromosomal region of 4q (59%), 8p (77%), and 16q (50%), whereas gains were noted in 1q (86%) and 8q (77%). All of these chromosomal arms were revealed to have frequent allelic imbalances by PCR-LOH analysis, however, 9% of chromosomal aberrations were detected only by CGH analysis and 2% were detected only by PCR-LOH analysis. Our results suggest that CGH analysis gives more precise results for the screening of chromosomal aberrations in HCCs than that of PCR-LOH analysis with randomly selected microsatellite markers. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 193~202 | - |
dc.relation.isPartOf | CANCER LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Carcinoma, Hepatocellular/genetics* | - |
dc.subject.MESH | Chromosome Deletion* | - |
dc.subject.MESH | Chromosome Mapping* | - |
dc.subject.MESH | Gene Duplication* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver Neoplasms/genetics* | - |
dc.subject.MESH | Loss of Heterozygosity* | - |
dc.subject.MESH | Polymerase Chain Reaction/methods | - |
dc.title | Assessment of chromosomal losses and gains in hepatocellular carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Joon Chang | - |
dc.contributor.googleauthor | Nam Gyun Kim | - |
dc.contributor.googleauthor | Zhe Piao | - |
dc.contributor.googleauthor | Chanil Park | - |
dc.contributor.googleauthor | Kang Sik Park | - |
dc.contributor.googleauthor | Young Ki Paik | - |
dc.contributor.googleauthor | Woo Jung Lee | - |
dc.contributor.googleauthor | Byong Ro Kim | - |
dc.contributor.googleauthor | Hoguen Kim | - |
dc.identifier.doi | 10.1016/S0304-3835(02)00083-6 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01183 | - |
dc.contributor.localId | A01710 | - |
dc.relation.journalcode | J00448 | - |
dc.identifier.eissn | 1872-7980 | - |
dc.identifier.pmid | 12048165 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0304383502000836 | - |
dc.subject.keyword | Allelic imbalance | - |
dc.subject.keyword | Comparative genomic hybridization | - |
dc.subject.keyword | Hepatocellular carcinomas | - |
dc.contributor.alternativeName | Kim, Ho Keun | - |
dc.contributor.alternativeName | Park, Chan Il | - |
dc.contributor.affiliatedAuthor | Kim, Ho Keun | - |
dc.contributor.affiliatedAuthor | Park, Chan Il | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 182 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 193 | - |
dc.citation.endPage | 202 | - |
dc.identifier.bibliographicCitation | CANCER LETTERS, Vol.182(2) : 193-202, 2002 | - |
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