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Factors predictive of response to Interferon-α therapy in Hepatitis C virus type 1b infection.

Authors
 Byung-Il Yeh  ;  Kwang Hyub Han  ;  Hyean Woo Lee  ;  Joon Hyung Sohn  ;  Wang Shick Ryu  ;  Do Jun Yoon  ;  Joonho Yoon  ;  Hyun Won Kim  ;  In Deok Kong  ;  Sei Jin Chang  ;  Jong Whan Choi 
Citation
 JOURNAL OF MEDICAL VIROLOGY, Vol.66(4) : 481-487, 2002 
Journal Title
JOURNAL OF MEDICAL VIROLOGY
ISSN
 0146-6615 
Issue Date
2002
MeSH
Adult ; Aged ; Amino Acid Sequence ; Antiviral Agents/therapeutic use* ; Female ; Hepacivirus/classification* ; Hepacivirus/drug effects ; Hepacivirus/genetics ; Hepatitis C/drugtherapy* ; Hepatitis C/virology ; Humans ; Interferon-alpha/therapeutic use* ; Male ; Middle Aged ; Molecular Sequence Data ; PredictiveValue of Tests ; RNA, Viral/blood* ; Sequence Analysis, DNA ; Treatment Outcome ; Viral Proteins/genetics*
Keywords
HCV RNA titer ; hypervariable region ; quasispecies ; IFN-a effect
Abstract
Interferon-α (IFN-α) has been used to treat hepatitis C Virus (HCV)-induced infection but has been effective in only about half of all patients. It is suggested that the different responses to IFN-α treatment in HCV infection may be influenced by HCV genotypes, HCV RNA titer at the beginning of IFN-α therapy, and the sequences of the interferon sensitivity determining region (ISDR). However, there have also been reports showing that these have no relation to an IFN-α effect. In a previous study, it was found that the nucleotide sequence variation in the hypervariable region (HVR) 1 of the HCV could predict the effect of IFN-α. In the present investigation, an attempt was made to determine the predictive factors of IFN-α therapy. Twenty-six patients with HCV infection were treated with IFN-α. Among these, 13 patients recovered after 3 to 6 months of IFN-α treatment, although the other 13 patients showed no response after 6 months of treatment with IFN-α. In order to determine the predictive factors of IFN-α therapy, the ALT levels, HCV genotypes, HCV serum titer, and the quasispecies of HVR 1 were compared between responders and non-responders. It is suggested that the variation in the HVR 1 and HCV serum titer can be used to predict the effect of IFN-α.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jmv.2169/abstract
DOI
10.1002/jmv.2169
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/143459
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