Cited 20 times in
Factors predictive of response to Interferon-α therapy in Hepatitis C virus type 1b infection.
DC Field | Value | Language |
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dc.contributor.author | 한광협 | - |
dc.date.accessioned | 2016-05-16T10:56:56Z | - |
dc.date.available | 2016-05-16T10:56:56Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0146-6615 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/143459 | - |
dc.description.abstract | Interferon-α (IFN-α) has been used to treat hepatitis C Virus (HCV)-induced infection but has been effective in only about half of all patients. It is suggested that the different responses to IFN-α treatment in HCV infection may be influenced by HCV genotypes, HCV RNA titer at the beginning of IFN-α therapy, and the sequences of the interferon sensitivity determining region (ISDR). However, there have also been reports showing that these have no relation to an IFN-α effect. In a previous study, it was found that the nucleotide sequence variation in the hypervariable region (HVR) 1 of the HCV could predict the effect of IFN-α. In the present investigation, an attempt was made to determine the predictive factors of IFN-α therapy. Twenty-six patients with HCV infection were treated with IFN-α. Among these, 13 patients recovered after 3 to 6 months of IFN-α treatment, although the other 13 patients showed no response after 6 months of treatment with IFN-α. In order to determine the predictive factors of IFN-α therapy, the ALT levels, HCV genotypes, HCV serum titer, and the quasispecies of HVR 1 were compared between responders and non-responders. It is suggested that the variation in the HVR 1 and HCV serum titer can be used to predict the effect of IFN-α. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 481~487 | - |
dc.relation.isPartOf | JOURNAL OF MEDICAL VIROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Amino Acid Sequence | - |
dc.subject.MESH | Antiviral Agents/therapeutic use* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hepacivirus/classification* | - |
dc.subject.MESH | Hepacivirus/drug effects | - |
dc.subject.MESH | Hepacivirus/genetics | - |
dc.subject.MESH | Hepatitis C/drugtherapy* | - |
dc.subject.MESH | Hepatitis C/virology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interferon-alpha/therapeutic use* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Molecular Sequence Data | - |
dc.subject.MESH | PredictiveValue of Tests | - |
dc.subject.MESH | RNA, Viral/blood* | - |
dc.subject.MESH | Sequence Analysis, DNA | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Viral Proteins/genetics* | - |
dc.title | Factors predictive of response to Interferon-α therapy in Hepatitis C virus type 1b infection. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Byung-Il Yeh | - |
dc.contributor.googleauthor | Kwang Hyub Han | - |
dc.contributor.googleauthor | Hyean Woo Lee | - |
dc.contributor.googleauthor | Joon Hyung Sohn | - |
dc.contributor.googleauthor | Wang Shick Ryu | - |
dc.contributor.googleauthor | Do Jun Yoon | - |
dc.contributor.googleauthor | Joonho Yoon | - |
dc.contributor.googleauthor | Hyun Won Kim | - |
dc.contributor.googleauthor | In Deok Kong | - |
dc.contributor.googleauthor | Sei Jin Chang | - |
dc.contributor.googleauthor | Jong Whan Choi | - |
dc.identifier.doi | 10.1002/jmv.2169 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04268 | - |
dc.relation.journalcode | J01587 | - |
dc.identifier.eissn | 1096-9071 | - |
dc.identifier.pmid | 11857525 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/jmv.2169/abstract | - |
dc.subject.keyword | HCV RNA titer | - |
dc.subject.keyword | hypervariable region | - |
dc.subject.keyword | quasispecies | - |
dc.subject.keyword | IFN-a effect | - |
dc.contributor.alternativeName | Han, Kwang Hyup | - |
dc.contributor.affiliatedAuthor | Han, Kwang Hyup | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 66 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 481 | - |
dc.citation.endPage | 487 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MEDICAL VIROLOGY, Vol.66(4) : 481-487, 2002 | - |
dc.identifier.rimsid | 53181 | - |
dc.type.rims | ART | - |
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