200 276

Cited 16 times in

Effect of Induced and Spontaneous Hypothermia on Survival Time of Uncontrolled Hemorrhagic Shock Rat Model

Authors
 Kyung Ryong Lee  ;  Sung Pil Chung  ;  In Chul Park  ;  Seung Ho Kim 
Citation
 YONSEI MEDICAL JOURNAL, Vol.43(4) : 511-517, 2002 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2002
MeSH
Animals ; Blood Pressure ; Body Temperature ; Hypothermia/physiopathology* ; Hypothermia, Induced* ; Male ; Rats ; Rats, Sprague-Dawley ; Shock, Hemorrhagic/mortality* ; Shock, Hemorrhagic/physiopathology ; Shock, Hemorrhagic/therapy
Keywords
uncontrolled hemorrhagic shock ; mild hypothermia
Abstract
We examined the hypothesis that mild hypothermia (rectal temperature 34℃) results in the same survival time, whether induced spontaneously or intentionally, during untreated, lethal, uncontrolled hemorrhagic shock in rats. Sixty-four Sprague-Dawley male rats were randomly assigned to normothermia (Nth) (n=19), spontaneous mild hypothermia (Sp.Hth) (n=25) or controlled mild hypothermia (Con.Hth) (n=20) groups. After blood withdrawal of 3 mL/100 g over 15 minutes, followed by 75% tail amputation under spontaneous breathing and light anesthesia by i.p. injection of pentobarbital sodium, rats were observed without fluid resuscitation or hemostasis for 180 minutes or until death. The initial temperature of the Nth group was artificially maintained throughout the experiment. For the mild hypothermia groups, the Sp.Hth group was exposed to ambient temperature while the Con. Hth group was actively cooled to a target rectal temperature of 34℃. In the Con.Hth group, all rats except one died before 180 minutes. All rats in the Nth group died within 38 minutes, and within 67 minutes in the Sp.Hth group. The average survival time was shortest in the Nth group at 20.3 ± 5.3 minutes, followed by the Sp.Hth group at 30.1 ± 13.5 minutes, and the Con.Hth group at 81.9 ± 39.8 minutes (p < 0.01). Tail bleed out volume was 0.51 ± 0.19, 0.26 ± 0.15 and 0.19 ± 0.12 mL/100 g in the Nth, Sp.Hth and Con.Hth groups, respectively (p < 0.05). In conclusion, spontaneous mild hypothermia did not prolong the survival time as much as controlled mild hypothermia in the rat model for untreated, lethal, uncontrolled hemorrhagic shock.
Files in This Item:
T200202307.pdf Download
DOI
10.3349/ymj.2002.43.4.511
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seung Ho(김승호)
Park, In Cheol(박인철) ORCID logo https://orcid.org/0000-0001-7033-766X
Lee, Kyeong Ryong(이경룡)
Chung, Sung Pil(정성필) ORCID logo https://orcid.org/0000-0002-3074-011X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/143427
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse