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한국인 급성골수성백혈병과 골수이형성증후군에서 Glutathione S-Transferase (GST) 유전자 결손분석

Other Titles
 Glutathione S-Transferase (GST) Gene Deletions in Korean Patients with Acute Myeloid Leukemia or Myelodysplastic Syndrome 
Authors
 우희연  ;  이경아  ;  홍영준  ;  박효순  ;  김선희 
Citation
 Korean Journal of Hematology (대한혈액학회지), Vol.37(4) : 265-269, 2002 
Journal Title
Korean Journal of Hematology(대한혈액학회지)
ISSN
 1125-0546 
Issue Date
2002
Keywords
Glutathione S-transferase(GST) gene deletion ; Acute myeoloid leukemia ; Myelodysplastic syndrome
Abstract
Background : There have been many studies on the association between the glutathione S- transferase (GST) genotype and the susceptibility to acute myeloid leukemia (AML)/myelodysplastic syndrome (MDS) and the results are still controversial. We tested whether the homozygous null genotype of GST mu 1 (GSTM1) and GST theta 1 (GSTT1) genes influences the risk for MDS and AML.

Methods :
We analyzed bone marrow DNA samples from 54 patients with AML or MDS (14 de novo AML, 7 secondary AML, and 33 MDS) and peripheral blood DNA samples from 75 cancer-free controls. The GSTM1 and GSTT1 genotypes were analyzed by multiplex polymerase chain reaction (PCR).

Results : The frequencies of GSTM1 null and GSTT1 null were not significantly increased in AML/MDS cases compared with those in controls.

Conclusion : Our data suggest that GSTM1 and GSTT1 null genotypes may not predispose to AML/MDS in Korean population.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Kyung A(이경아) ORCID logo https://orcid.org/0000-0001-5320-6705
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/143416
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