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한국인 급성골수성백혈병과 골수이형성증후군에서 Glutathione S-Transferase (GST) 유전자 결손분석
DC Field | Value | Language |
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dc.contributor.author | 이경아 | - |
dc.date.accessioned | 2016-05-16T10:55:43Z | - |
dc.date.available | 2016-05-16T10:55:43Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 1125-0546 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/143416 | - |
dc.description.abstract | Background : There have been many studies on the association between the glutathione S- transferase (GST) genotype and the susceptibility to acute myeloid leukemia (AML)/myelodysplastic syndrome (MDS) and the results are still controversial. We tested whether the homozygous null genotype of GST mu 1 (GSTM1) and GST theta 1 (GSTT1) genes influences the risk for MDS and AML. Methods : We analyzed bone marrow DNA samples from 54 patients with AML or MDS (14 de novo AML, 7 secondary AML, and 33 MDS) and peripheral blood DNA samples from 75 cancer-free controls. The GSTM1 and GSTT1 genotypes were analyzed by multiplex polymerase chain reaction (PCR). Results : The frequencies of GSTM1 null and GSTT1 null were not significantly increased in AML/MDS cases compared with those in controls. Conclusion : Our data suggest that GSTM1 and GSTT1 null genotypes may not predispose to AML/MDS in Korean population. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 265~269 | - |
dc.relation.isPartOf | Korean Journal of Hematology (대한혈액학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 한국인 급성골수성백혈병과 골수이형성증후군에서 Glutathione S-Transferase (GST) 유전자 결손분석 | - |
dc.title.alternative | Glutathione S-Transferase (GST) Gene Deletions in Korean Patients with Acute Myeloid Leukemia or Myelodysplastic Syndrome | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | 우희연 | - |
dc.contributor.googleauthor | 이경아 | - |
dc.contributor.googleauthor | 홍영준 | - |
dc.contributor.googleauthor | 박효순 | - |
dc.contributor.googleauthor | 김선희 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02647 | - |
dc.relation.journalcode | J02034 | - |
dc.subject.keyword | Glutathione S-transferase(GST) gene deletion | - |
dc.subject.keyword | Acute myeoloid leukemia | - |
dc.subject.keyword | Myelodysplastic syndrome | - |
dc.contributor.alternativeName | Lee, Kyung A | - |
dc.contributor.affiliatedAuthor | Lee, Kyung A | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 37 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 265 | - |
dc.citation.endPage | 269 | - |
dc.identifier.bibliographicCitation | Korean Journal of Hematology (대한혈액학회지), Vol.37(4) : 265-269, 2002 | - |
dc.identifier.rimsid | 53154 | - |
dc.type.rims | ART | - |
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