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거대봉선핵의 자극 및 아편계 약물의 이온영동적 주입에 의한 신경병리성 통증의 억제 효과

Other Titles
 Inhibition of Neuropathic Pain by Electrical Stimulation of the Nucleus Raphe Magnus and Microiontophoretic Application of Opiates in Rats 
Authors
 이배환  ;  윤진선  ;  원란  ;  박용구  ;  정상섭 
Citation
 Journal of the Korean Pain Research Society (통증), Vol.11(1) : 76-82, 2001 
Journal Title
Journal of the Korean Pain Research Society(통증)
ISSN
 1226-3079 
Issue Date
2001
Abstract
Background : Neuropathic pain which is a chronic pain state can be produced by injury of peripheral nerves or tissues. Traditionally, opioids have been used to alleviate pain but have not been effective in treating neuropathic pain. The present study was conducted to elucidate whether activation of descending pain inhibition system originating in the nucleus raphe magnus and/or microiontophoretic application of opiates can alleviate neuropathic symptoms in an animal model of neuropathic pain.
Methods : Under halothane anesthesia, male Sprague-Dawley rats were subjected to peripheral nerve injury. After behavioral tests for neuropathic pain, electrophysiological study including electrical stimulation of the nucleus raphe magnus and microiontophoretic application of opiates was performed.
Results : Mechanical allodynia, cold allodynia, and spontaneous pain were developed gradually after injury to the tibial and sural nerves, peaking at 14 days postoperatively. Eletrical stimulation of the nucleus raphe magnus inhibited the responses of spinal dorsal horn neurons to von Frey filament and acetone. Microiontophoretically ejected DAMGO, DALDA, and U-62066 which are μ-, δ-, and κ- opioid receptor agonists, respectively, also inhibited the responses of spinal neurons to external stimuli.
Conclusions : The results suggest that opioid receptors may be involved in modulation of neuropathic pain at the level of the spinal cord and the modulation may be related to the activation of the descending pain inhibition system from the brain stem.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Park, Yong Gou(박용구)
Won, Ran(원란)
Yoon, Jin Sun(윤진선)
Lee, Bae Hwan(이배환) ORCID logo https://orcid.org/0000-0003-4719-9021
Chung, Sang Sup(정상섭)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/143090
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