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Capsaicin-induced Relaxation in Rabbit Coronary Artery

Authors
 Dongsoo YEON  ;  Seongchun KWON  ;  Youngho LEE  ;  Joongwoo LEEM  ;  Taicksang NAM  ;  Ducksun AHN 
Citation
 Journal of Veterinary Medical Science, Vol.63(5) : 499-503, 2001 
Journal Title
 Journal of Veterinary Medical Science 
ISSN
 0916-7250 
Issue Date
2001
Abstract
In the present study mechanism of inhibitory effects of capsaicin on the contractility of rabbit coronary artery were studied by measurement of isometric tension and intracellular Ca2+ concentration. Capsaicin (1 μM to 30 μM) relaxed the coronary artery pre-contracted with prostaglandin (PG) F2α (1 μM) in a concentration-dependent manner. The PGF2 α-induced increase in intracellular Ca2+ concentration was also inhibited. The effects of capsaicin were readily reversed by washing capsaicin from the bath. Capsaicin-induced relaxation was not attenuated by pretreatment with capsazepine (1 μM), a blocker of vanilloid receptor or ruthenium red (1 μM), a blocker of non-selective cation channel. Previous exposure to a high concentration of capsaicin (100 μM) or repeated application of capsaicin did not eliminate the relaxation response to subsequent application of capsaicin. Increasing the external K+ concentration to 80 mM significantly attenuated the capsaicin-induced relaxation with simultaneous change in intracellular Ca2+ concentration. Pretreatment with iberiotoxin (100 nM), a blocker of Ca2+-activated K+ channel, only partially inhibited the capsaicin-induced relaxation. However, application of 4-aminopyridine (4-AP, 1 mM), a blocker of delayed rectifier K+ current significantly inhibited the capsaicin-induced relaxation with concomitant attenuation of the effect on intracellular Ca2+ concentration. These results indicate that capsaicin may have a direct relaxing effect on the smooth muscle contractility, and relaxation may be due to activation of the 4-AP-sensitive, delayed rectifier K+ channels in the rabbit coronary artery.
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DOI
10.1292/jvms.63.499
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
남택상(Nam, Taick Sang)
안덕선(Ahn, Duk Sun) ORCID logo https://orcid.org/0000-0001-9351-6951
이영호(Lee, Young Ho) ORCID logo https://orcid.org/0000-0002-5749-1045
임중우(Leem, Joong Woo) ORCID logo https://orcid.org/0000-0002-1605-2230
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142871
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