Cited 13 times in
Capsaicin-induced Relaxation in Rabbit Coronary Artery
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 남택상 | - |
dc.contributor.author | 안덕선 | - |
dc.contributor.author | 이영호 | - |
dc.contributor.author | 임중우 | - |
dc.date.accessioned | 2016-02-19T11:18:54Z | - |
dc.date.available | 2016-02-19T11:18:54Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0916-7250 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/142871 | - |
dc.description.abstract | In the present study mechanism of inhibitory effects of capsaicin on the contractility of rabbit coronary artery were studied by measurement of isometric tension and intracellular Ca2+ concentration. Capsaicin (1 μM to 30 μM) relaxed the coronary artery pre-contracted with prostaglandin (PG) F2α (1 μM) in a concentration-dependent manner. The PGF2 α-induced increase in intracellular Ca2+ concentration was also inhibited. The effects of capsaicin were readily reversed by washing capsaicin from the bath. Capsaicin-induced relaxation was not attenuated by pretreatment with capsazepine (1 μM), a blocker of vanilloid receptor or ruthenium red (1 μM), a blocker of non-selective cation channel. Previous exposure to a high concentration of capsaicin (100 μM) or repeated application of capsaicin did not eliminate the relaxation response to subsequent application of capsaicin. Increasing the external K+ concentration to 80 mM significantly attenuated the capsaicin-induced relaxation with simultaneous change in intracellular Ca2+ concentration. Pretreatment with iberiotoxin (100 nM), a blocker of Ca2+-activated K+ channel, only partially inhibited the capsaicin-induced relaxation. However, application of 4-aminopyridine (4-AP, 1 mM), a blocker of delayed rectifier K+ current significantly inhibited the capsaicin-induced relaxation with concomitant attenuation of the effect on intracellular Ca2+ concentration. These results indicate that capsaicin may have a direct relaxing effect on the smooth muscle contractility, and relaxation may be due to activation of the 4-AP-sensitive, delayed rectifier K+ channels in the rabbit coronary artery. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 499~503 | - |
dc.relation.isPartOf | JOURNAL OF VETERINARY MEDICAL SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | 4-Aminopyridine/pharmacology | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Calcium/metabolism | - |
dc.subject.MESH | Capsaicin/analogs & derivatives* | - |
dc.subject.MESH | Capsaicin/antagonists & inhibitors | - |
dc.subject.MESH | Capsaicin/pharmacology* | - |
dc.subject.MESH | Coronary Vessels/drug effects* | - |
dc.subject.MESH | Coronary Vessels/physiology | - |
dc.subject.MESH | Dinoprost/pharmacology | - |
dc.subject.MESH | Drug Interactions | - |
dc.subject.MESH | Fluorescent Dyes/chemistry | - |
dc.subject.MESH | Fura-2/analogs & derivatives* | - |
dc.subject.MESH | Fura-2/chemistry | - |
dc.subject.MESH | In Vitro Techniques | - |
dc.subject.MESH | Isometric Contraction/drug effects | - |
dc.subject.MESH | Isometric Contraction/physiology | - |
dc.subject.MESH | Muscle Relaxation/drug effects* | - |
dc.subject.MESH | Muscle Relaxation/physiology | - |
dc.subject.MESH | Muscle, Smooth, Vascular/drug effects* | - |
dc.subject.MESH | Muscle, Smooth, Vascular/physiology | - |
dc.subject.MESH | Peptides/pharmacology | - |
dc.subject.MESH | Potassium Channel Blockers | - |
dc.subject.MESH | Potassium Channels/physiology | - |
dc.subject.MESH | Rabbits | - |
dc.subject.MESH | Ruthenium Red/pharmacology | - |
dc.title | Capsaicin-induced Relaxation in Rabbit Coronary Artery | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Physiology (생리학) | - |
dc.contributor.googleauthor | Dongsoo YEON | - |
dc.contributor.googleauthor | Seongchun KWON | - |
dc.contributor.googleauthor | Youngho LEE | - |
dc.contributor.googleauthor | Joongwoo LEEM | - |
dc.contributor.googleauthor | Taicksang NAM | - |
dc.contributor.googleauthor | Ducksun AHN | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01271 | - |
dc.contributor.localId | A02223 | - |
dc.contributor.localId | A02968 | - |
dc.contributor.localId | A03409 | - |
dc.relation.journalcode | J01926 | - |
dc.identifier.eissn | 1347-7439 | - |
dc.identifier.pmid | 11411493 | - |
dc.contributor.alternativeName | Nam, Taick Sang | - |
dc.contributor.alternativeName | Ahn, Duk Sun | - |
dc.contributor.alternativeName | Lee, Young Ho | - |
dc.contributor.alternativeName | Leem, Joong Woo | - |
dc.contributor.affiliatedAuthor | Nam, Taick Sang | - |
dc.contributor.affiliatedAuthor | Ahn, Duk Sun | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.contributor.affiliatedAuthor | Leem, Joong Woo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 63 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 499 | - |
dc.citation.endPage | 503 | - |
dc.identifier.bibliographicCitation | JOURNAL OF VETERINARY MEDICAL SCIENCE, Vol.63(5) : 499-503, 2001 | - |
dc.identifier.rimsid | 39539 | - |
dc.type.rims | ART | - |
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