0 633

Cited 53 times in

Oxidative Stress and Neurodegeneration in Prion Diseases

Authors
 Jae-Il Kim  ;  Seung-Il Choi  ;  Nam-Ho Kim  ;  Jae-Kwang Jin  ;  Eun-Kyoung Choi  ;  Richard I. Carp  ;  Yong-Sun Kim 
Citation
 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, Vol.928 : 182-186, 2001 
Journal Title
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
ISSN
 0077-8923 
Issue Date
2001
MeSH
Animals ; Brain/metabolism ; Brain/pathology ; Gene Expression Regulation ; Humans ; Models, Biological ; NF-kappa B/metabolism ; Nerve Degeneration/metabolism* ; Nerve Tissue Proteins/metabolism ; Neuroglia/metabolism ; Neuroglia/pathology ; Neurons/metabolism* ; Neurons/pathology ; Oxidation-Reduction ; Oxidative Stress* ; PrPC Proteins/metabolism ; PrPSc Proteins/metabolism ; Prion Diseases/metabolism* ; Prion Diseases/pathology ; Reactive Oxygen Species/metabolism ; Scrapie/metabolism ; Scrapie/pathology ; Sheep ; Transcription, Genetic
Keywords
neurodegeneration ; oxidative stress ; prion disease
Abstract
Transmissible spongiform encephalopathies (TSEs), also termed prion diseases, are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of these diseases is thought to be associated with the conversion of a normal protein, PrPC, into an infectious, pathogenic form, PrPSc. The PrPSc form shows greater protease resistance than PrPC and accumulates in affected individuals, often in the form of extracellular plaques. The pathogenesis and the molecular basis of neuronal cell death in these diseases are not well understood. Oxidative stress has been proposed to play an important role in the pathogenesis of several neurodegenerative disorders. In the present study, evidence of oxidative stress in scrapie, the archetype disease of the TSEs, is discussed. In addition, the mechanisms whereby oxidative stress could lead to neuronal degeneration are described.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2001.tb05648.x/abstract
DOI
10.1111/j.1749-6632.2001.tb05648.x
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
Yonsei Authors
Choi, Seung Il(최승일) ORCID logo https://orcid.org/0000-0001-7168-8795
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142837
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links