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Xenopus oocytes에서 발현된 유전자재조합 세로토닌 제3형 수용체에 대한 한국산 홍삼 사포닌의 효과

Other Titles
 The Effect of Korean Red Ginseng Saponins on the Recombinant Serotonin Type 3 Receptor Expressed in Xenopus Oocytes 
Authors
 구본녀  ;  강정완  ;  배선준  ;  김미경  ;  고성룡  ;  민경태  ;  강정환 
Citation
 JOURNAL OF GINSENG RESEARCH, Vol.25(2) : 74-81, 2001 
Journal Title
JOURNAL OF GINSENG RESEARCH(고려인삼학회지)
ISSN
 1226-8453 
Issue Date
2001
Keywords
ginseng saponin ; xenopus oocytes ; recombinant serotonin type 3 receptor ; voltage clamp technique
Abstract
The effect of Korean Ginseng saponins (total saponin, PD saponin and PT saponin) on the serotonin type 3 receptor, which is known to be involved in nausea and vomiting following anticancer chemotherapy or the general anesthesia, was investigated. after in vitro transcribed recombinant serotonin type 3 receptor in the Xenopus laevis oocyte, classic two electrodes voltage clamp technique was used. All of ginseng saponins inhibited the response of the agonist, serotonin, on the serotonin type 3 receptor in a dose-dependent manner. PT saponin showed to have the inhibitory effect more than 2 times as potent as PD saponin. Total saponin shifted the serotonin dose response plot to the right (EC50/, 0.70±0.17 μM into 3.57±1.42 μM, and Hill coefficient, 2.14±0.60 into 1.52±1.00). Ginseng saponin did not change the reversal potential (∼0 mV) of serotonin type 3 receptor. These results suggest that Korean ginseng saponin may have the inhibitory effect on serotonin type 3 receptor.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Min, Kyeong Tae(민경태) ORCID logo https://orcid.org/0000-0002-3299-4500
Bai, Sun Joon(배선준) ORCID logo https://orcid.org/0000-0001-5027-3232
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142799
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