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Xenopus oocytes에서 발현된 유전자재조합 세로토닌 제3형 수용체에 대한 한국산 홍삼 사포닌의 효과

DC Field Value Language
dc.contributor.author민경태-
dc.contributor.author배선준-
dc.date.accessioned2016-02-19T11:16:56Z-
dc.date.available2016-02-19T11:16:56Z-
dc.date.issued2001-
dc.identifier.issn1226-8453-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/142799-
dc.description.abstractThe effect of Korean Ginseng saponins (total saponin, PD saponin and PT saponin) on the serotonin type 3 receptor, which is known to be involved in nausea and vomiting following anticancer chemotherapy or the general anesthesia, was investigated. after in vitro transcribed recombinant serotonin type 3 receptor in the Xenopus laevis oocyte, classic two electrodes voltage clamp technique was used. All of ginseng saponins inhibited the response of the agonist, serotonin, on the serotonin type 3 receptor in a dose-dependent manner. PT saponin showed to have the inhibitory effect more than 2 times as potent as PD saponin. Total saponin shifted the serotonin dose response plot to the right (EC50/, 0.70±0.17 μM into 3.57±1.42 μM, and Hill coefficient, 2.14±0.60 into 1.52±1.00). Ginseng saponin did not change the reversal potential (∼0 mV) of serotonin type 3 receptor. These results suggest that Korean ginseng saponin may have the inhibitory effect on serotonin type 3 receptor.-
dc.description.statementOfResponsibilityopen-
dc.format.extent74~81-
dc.relation.isPartOfJOURNAL OF GINSENG RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleXenopus oocytes에서 발현된 유전자재조합 세로토닌 제3형 수용체에 대한 한국산 홍삼 사포닌의 효과-
dc.title.alternativeThe Effect of Korean Red Ginseng Saponins on the Recombinant Serotonin Type 3 Receptor Expressed in Xenopus Oocytes-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology (마취통증의학)-
dc.contributor.googleauthor구본녀-
dc.contributor.googleauthor강정완-
dc.contributor.googleauthor배선준-
dc.contributor.googleauthor김미경-
dc.contributor.googleauthor고성룡-
dc.contributor.googleauthor민경태-
dc.contributor.googleauthor강정환-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01400-
dc.contributor.localIdA01795-
dc.relation.journalcodeJ01425-
dc.identifier.eissn2093-4947-
dc.subject.keywordginseng saponin-
dc.subject.keywordxenopus oocytes-
dc.subject.keywordrecombinant serotonin type 3 receptor-
dc.subject.keywordvoltage clamp technique-
dc.contributor.alternativeNameMin, Kyeong Tae-
dc.contributor.alternativeNameBai, Sun Joon-
dc.contributor.affiliatedAuthorMin, Kyeong Tae-
dc.contributor.affiliatedAuthorBai, Sun Joon-
dc.rights.accessRightsfree-
dc.citation.volume25-
dc.citation.number2-
dc.citation.startPage74-
dc.citation.endPage81-
dc.identifier.bibliographicCitationJOURNAL OF GINSENG RESEARCH, Vol.25(2) : 74-81, 2001-
dc.identifier.rimsid29862-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

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