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Xenopus oocytes에서 발현된 유전자재조합 세로토닌 제3형 수용체에 대한 한국산 홍삼 사포닌의 효과
DC Field | Value | Language |
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dc.contributor.author | 민경태 | - |
dc.contributor.author | 배선준 | - |
dc.date.accessioned | 2016-02-19T11:16:56Z | - |
dc.date.available | 2016-02-19T11:16:56Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 1226-8453 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/142799 | - |
dc.description.abstract | The effect of Korean Ginseng saponins (total saponin, PD saponin and PT saponin) on the serotonin type 3 receptor, which is known to be involved in nausea and vomiting following anticancer chemotherapy or the general anesthesia, was investigated. after in vitro transcribed recombinant serotonin type 3 receptor in the Xenopus laevis oocyte, classic two electrodes voltage clamp technique was used. All of ginseng saponins inhibited the response of the agonist, serotonin, on the serotonin type 3 receptor in a dose-dependent manner. PT saponin showed to have the inhibitory effect more than 2 times as potent as PD saponin. Total saponin shifted the serotonin dose response plot to the right (EC50/, 0.70±0.17 μM into 3.57±1.42 μM, and Hill coefficient, 2.14±0.60 into 1.52±1.00). Ginseng saponin did not change the reversal potential (∼0 mV) of serotonin type 3 receptor. These results suggest that Korean ginseng saponin may have the inhibitory effect on serotonin type 3 receptor. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 74~81 | - |
dc.relation.isPartOf | JOURNAL OF GINSENG RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Xenopus oocytes에서 발현된 유전자재조합 세로토닌 제3형 수용체에 대한 한국산 홍삼 사포닌의 효과 | - |
dc.title.alternative | The Effect of Korean Red Ginseng Saponins on the Recombinant Serotonin Type 3 Receptor Expressed in Xenopus Oocytes | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology (마취통증의학) | - |
dc.contributor.googleauthor | 구본녀 | - |
dc.contributor.googleauthor | 강정완 | - |
dc.contributor.googleauthor | 배선준 | - |
dc.contributor.googleauthor | 김미경 | - |
dc.contributor.googleauthor | 고성룡 | - |
dc.contributor.googleauthor | 민경태 | - |
dc.contributor.googleauthor | 강정환 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01400 | - |
dc.contributor.localId | A01795 | - |
dc.relation.journalcode | J01425 | - |
dc.identifier.eissn | 2093-4947 | - |
dc.subject.keyword | ginseng saponin | - |
dc.subject.keyword | xenopus oocytes | - |
dc.subject.keyword | recombinant serotonin type 3 receptor | - |
dc.subject.keyword | voltage clamp technique | - |
dc.contributor.alternativeName | Min, Kyeong Tae | - |
dc.contributor.alternativeName | Bai, Sun Joon | - |
dc.contributor.affiliatedAuthor | Min, Kyeong Tae | - |
dc.contributor.affiliatedAuthor | Bai, Sun Joon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 25 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 74 | - |
dc.citation.endPage | 81 | - |
dc.identifier.bibliographicCitation | JOURNAL OF GINSENG RESEARCH, Vol.25(2) : 74-81, 2001 | - |
dc.identifier.rimsid | 29862 | - |
dc.type.rims | ART | - |
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