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비병변성 신피질 간질환자의 발작기 대뇌 피질뇌파 분석

Other Titles
 Analysis of Ictal Electrocorticographic Features in Nonlesional Neocortical Epilepsy 
 박선아  ;  임성룡  ;  허경  ;  박수철  ;  장진우  ;  최중언  ;  김태승  ;  이병인 
 Journal of Korean Epilepsy Society (대한간질학회지), Vol.5(1) : 33-40, 2001 
Journal Title
 Journal of Korean Epilepsy Society (대한간질학회지) 
Issue Date
electrocorticography ; epilepsy surgery ; neocortical epilepsy ; prognosis ; subdural grid electrode
Background: To characterize the ictal electrocorticographic features in relation to surgical outcome in nonlesional neocortical epilepsy (NE). Methods: Seventeen patients with intractable NE underwent surgeries after chronic subdural recordings. All patients did not have any lesions on brain MRI, which was confirmed by pathology postoperatively. One hundred and eighty one ictal EEGs recorded from subdural electrodes were analyzed. Surgical outcome was determined by seizure reduction rate, and free or more than 75% reduction was defined as favorable outcome. The mean duration of follow-up was 55+/-8.7 months. Results: Reproducible ictal onset zone (IOZ) in more than a half of seizures (p=0.002), and persistent ictal discharges in IOZ from the onset to the end of seizure were found more frequently in the patients with good outcome (p=0.004). Ictal onset patterns consisting of low voltage fast or high amplitude beta spikes predicted a good surgical outcome while rhythmic sinusoidal activity or rhythmic spike/sharp wave were predictive of poor outcome (p=0.01). The ictal onset rhythm consisted of gamma or beta frequencies was more prevalent in the favorable group (p=0.003). Conclusions: The presence of stable ictal circuit suggested by the consistent earliest activation in more than 50% of seizures and the active participation of IOZ throughout the attack were valuable prognostic factors in addition to the morphology and frequency of ictal onset rhythm.
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1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Byung In(이병인)
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