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Activity of the APCCdh1 form of the anaphase-promoting complex persists until S phase and prevents the premature expression of Cdc20p

Authors
 James N. Huang  ;  Iha Park  ;  Eric Ellingson  ;  Laurie E. Littlepage  ;  David Pellman 
Citation
 Journal of Cell Biology, Vol.154(1) : 85-94, 2001 
Journal Title
 Journal of Cell Biology 
ISSN
 0021-9525 
Issue Date
2001
Abstract
Cell cycle progression is driven by waves of cyclin expression coupled with regulated protein degradation. An essential step for initiating mitosis is the inactivation of proteolysis mediated by the anaphase-promoting complex/cyclosome (APC/C) bound to its regulator Cdh1p/Hct1p. Yeast APCCdh1 was proposed previously to be inactivated at Start by G1 cyclin/cyclin-dependent kinase (CDK). Here, we demonstrate that in a normal cell cycle APCCdh1 is inactivated in a graded manner and is not extinguished until S phase. Complete inactivation of APCCdh1 requires S phase cyclins. Further, persistent APCCdh1 activity throughout G1 helps to ensure the proper timing of Cdc20p expression. This suggests that S phase cyclins have an important role in allowing the accumulation of mitotic cyclins and further suggests a regulatory loop among S phase cyclins, APCCdh1, and APCCdc20.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142508
DOI
10.1083/jcb.200102007
Appears in Collections:
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소)
Yonsei Authors
박이하(Park, Iha)
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