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Activity of the APCCdh1 form of the anaphase-promoting complex persists until S phase and prevents the premature expression of Cdc20p

DC Field Value Language
dc.contributor.author박이하-
dc.date.accessioned2016-02-19T11:09:01Z-
dc.date.available2016-02-19T11:09:01Z-
dc.date.issued2001-
dc.identifier.issn0021-9525-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/142508-
dc.description.abstractCell cycle progression is driven by waves of cyclin expression coupled with regulated protein degradation. An essential step for initiating mitosis is the inactivation of proteolysis mediated by the anaphase-promoting complex/cyclosome (APC/C) bound to its regulator Cdh1p/Hct1p. Yeast APCCdh1 was proposed previously to be inactivated at Start by G1 cyclin/cyclin-dependent kinase (CDK). Here, we demonstrate that in a normal cell cycle APCCdh1 is inactivated in a graded manner and is not extinguished until S phase. Complete inactivation of APCCdh1 requires S phase cyclins. Further, persistent APCCdh1 activity throughout G1 helps to ensure the proper timing of Cdc20p expression. This suggests that S phase cyclins have an important role in allowing the accumulation of mitotic cyclins and further suggests a regulatory loop among S phase cyclins, APCCdh1, and APCCdc20.-
dc.description.statementOfResponsibilityopen-
dc.format.extent85~94-
dc.relation.isPartOfJOURNAL OF CELL BIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleActivity of the APCCdh1 form of the anaphase-promoting complex persists until S phase and prevents the premature expression of Cdc20p-
dc.typeArticle-
dc.contributor.collegeResearcher Institutes (부설 연구소)-
dc.contributor.departmentOral Cancer Research Institute (구강종양연구소)-
dc.contributor.googleauthorJames N. Huang-
dc.contributor.googleauthorIha Park-
dc.contributor.googleauthorEric Ellingson-
dc.contributor.googleauthorLaurie E. Littlepage-
dc.contributor.googleauthorDavid Pellman-
dc.identifier.doi10.1083/jcb.200102007-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01623-
dc.relation.journalcodeJ01300-
dc.identifier.eissn1540-8140-
dc.subject.keywordcell cycle-
dc.subject.keywordcyclin-dependent kinases-
dc.subject.keywordmitosis-
dc.subject.keywordS phase-
dc.subject.keywordubiquitin-
dc.contributor.alternativeNamePark, Iha-
dc.contributor.affiliatedAuthorPark, Iha-
dc.rights.accessRightsfree-
dc.citation.volume154-
dc.citation.number1-
dc.citation.startPage85-
dc.citation.endPage94-
dc.identifier.bibliographicCitationJOURNAL OF CELL BIOLOGY, Vol.154(1) : 85-94, 2001-
Appears in Collections:
2. College of Dentistry (치과대학) > Research Institute (부설연구소) > 1. Journal Papers

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