138 143

난치성 간질의 미주신경자극 치료 : 18개월 추적 다기관 임상연구

Other Titles
 Vagus Nerve Stimulation Therapy in Refractory Epilepsy:18-Month Follow-up Multicenter Study 
Authors
 이병인  ;  허경  ;  이상암  ;  강중구  ;  이상건  ;  홍승봉  ;  서대원  ;  김흥동  ;  장진우  ;  이정교  ;  정천기  ;  홍승철  ;  황용순 
Citation
 Journal of Korean Epilepsy Society (대한간질학회지), Vol.5(1) : 46-51, 2001 
Journal Title
 Journal of Korean Epilepsy Society  (대한간질학회지) 
ISSN
 1226-6965 
Issue Date
2001
Abstract
Purpose: Vagus nerve stimulation (VNS) with the NeuroCybernetic Prosthesis (NCP) is a recently approved treatment for patients with medically intractable epilepsy in Korea, who are unsuitable candidates for conventional epilepsy surgery. This is the first report about the efficacy and safety of VNS in Korea. Methods: Fourteen patients (male 9 and female 5) recruited from 5 epilepsy centers were treated with VNS for 18 months : 13 suffered from partial epilepsy and 1 from Lennox-Gastaut syndrome. Mean age was 24 years (range : 7-45 years) and mean age at seizure onset 10.9 years (range : 0.5-41 years). All had medically intractable epilepsy and 4 patients had the previous history of epilepsy surgery. They were prospectively assessed at 3, 12, and 18 months after VNS with regard to seizure frequencies and side effects. Results: The number of patients achieved greater than 50% reduction of seizure frequency were 4, 6, and 6 (43%) at 3-, 12-, and 18-month follow-up respectively. Two patients who had showed initial improvement (at 3 month follow-up) returned to the baseline overtime. Four patients without initial improvement had more than 50% reduction of seizure frequency at 12-month follow-up. Side effects were usually mild and related to the period of stimulation : hoarseness, dysphonia, coughing, and local paresthesia. In 3 patients, the stimulators were turned off, due to the patient’s refusal, severe dental pain, and dyspnea in each patient. Conclusions: Our data suggest that vagus nerve stimulation is an effective and safe adjunctive treatment for patients with medically refractory epilepsy. One should pay attention to rare but potentially serious adverse effects including dyspnea.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142485
Files in This Item:
T200102337.pdf Download
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실)
Yonsei Authors
김흥동(Kim, Heung Dong)
이병인(Lee, Byung In)
Export
RIS (EndNote)
XLS (Excel)
XML
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse