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The role of peripheral N-methyl-d-aspartate receptors in Freund's complete adjuvant induced mechanical hyperalgesia in rats

Authors
 Joong Woo Leem ; Jae Hyun Hwang ; Yoon Choi ; Min Kyung Kim ; Hyoungsup Park ; Seung Joon Hwang 
Citation
 Neuroscience Letters, Vol.297(3) : 155~158, 2001 
Journal Title
 Neuroscience Letters 
ISSN
 0304-3940 
Issue Date
2001
Abstract
We investigated the role of excitatory amino acid receptors in mechanical hyperalgesia induced by subcutaneous injection of Freund's complete adjuvant (FCA) into the rat hind paw. In normal rats, an intraplantar (i.pl.) injection of l-glutamate, but not of d-glutamate (3 pmol/0.1 ml each) produced a mechanical hyperalgesia in the hind paw with a lowered paw-withdrawal threshold to pressure. In rats that developed mechanical hyperalgesia associated with inflammation in the hind paw following i.pl. injection of FCA (0.15 ml), the injection of N-methyl-d-aspartate (NMDA) receptor antagonist, MK-801 (1 pmol/0.1 ml) into the inflamed paw increased the paw pressure threshold. On the other hand, the injection of non-NMDA receptor antagonist, 6-cyano-7-nitroqiunoxaline-2,3-dione (CNQX, 10 pmol/0.1 ml) into the inflamed paw had no effect on FCA-induced lowering of the paw pressure threshold. The results suggest that NMDA, but not non-NMDA receptors play a substantial role in mediating the development of mechanical hyperalgesia induced in the inflamed paw following i.pl. FCA injection.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/142466
DOI
10.1016/S0304-3940(00)01662-1
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Physiology
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0304394000016621
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