Cited 34 times in
The role of peripheral N-methyl-d-aspartate receptors in Freund's complete adjuvant induced mechanical hyperalgesia in rats
DC Field | Value | Language |
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dc.contributor.author | 임중우 | - |
dc.date.accessioned | 2016-02-19T11:07:54Z | - |
dc.date.available | 2016-02-19T11:07:54Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0304-3940 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/142466 | - |
dc.description.abstract | We investigated the role of excitatory amino acid receptors in mechanical hyperalgesia induced by subcutaneous injection of Freund's complete adjuvant (FCA) into the rat hind paw. In normal rats, an intraplantar (i.pl.) injection of l-glutamate, but not of d-glutamate (3 pmol/0.1 ml each) produced a mechanical hyperalgesia in the hind paw with a lowered paw-withdrawal threshold to pressure. In rats that developed mechanical hyperalgesia associated with inflammation in the hind paw following i.pl. injection of FCA (0.15 ml), the injection of N-methyl-d-aspartate (NMDA) receptor antagonist, MK-801 (1 pmol/0.1 ml) into the inflamed paw increased the paw pressure threshold. On the other hand, the injection of non-NMDA receptor antagonist, 6-cyano-7-nitroqiunoxaline-2,3-dione (CNQX, 10 pmol/0.1 ml) into the inflamed paw had no effect on FCA-induced lowering of the paw pressure threshold. The results suggest that NMDA, but not non-NMDA receptors play a substantial role in mediating the development of mechanical hyperalgesia induced in the inflamed paw following i.pl. FCA injection. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 155~158 | - |
dc.relation.isPartOf | NEUROSCIENCE LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | 6-Cyano-7-nitroquinoxaline-2,3-dione/pharmacology | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Dizocilpine Maleate/pharmacology | - |
dc.subject.MESH | Excitatory Amino Acid Antagonists/pharmacology | - |
dc.subject.MESH | Freund's Adjuvant | - |
dc.subject.MESH | Glutamic Acid/pharmacology | - |
dc.subject.MESH | Hindlimb/physiopathology | - |
dc.subject.MESH | Hyperalgesia/chemically induced | - |
dc.subject.MESH | Hyperalgesia/metabolism* | - |
dc.subject.MESH | Hyperalgesia/physiopathology | - |
dc.subject.MESH | Inflammation/chemically induced | - |
dc.subject.MESH | Inflammation/physiopathology | - |
dc.subject.MESH | Isomerism | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Pain Measurement/drug effects | - |
dc.subject.MESH | Pain Threshold/drug effects | - |
dc.subject.MESH | Peripheral Nervous System/drug effects | - |
dc.subject.MESH | Peripheral Nervous System/metabolism* | - |
dc.subject.MESH | Peripheral Nervous System/physiopathology | - |
dc.subject.MESH | Physical Stimulation | - |
dc.subject.MESH | Pressure | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors | - |
dc.subject.MESH | Receptors, N-Methyl-D-Aspartate/metabolism* | - |
dc.title | The role of peripheral N-methyl-d-aspartate receptors in Freund's complete adjuvant induced mechanical hyperalgesia in rats | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Physiology (생리학) | - |
dc.contributor.googleauthor | Joong Woo Leem | - |
dc.contributor.googleauthor | Jae Hyun Hwang | - |
dc.contributor.googleauthor | Seung Joon Hwang | - |
dc.contributor.googleauthor | Hyoungsup Park | - |
dc.contributor.googleauthor | Min Kyung Kim | - |
dc.contributor.googleauthor | Yoon Choi | - |
dc.identifier.doi | 10.1016/S0304-3940(00)01662-1 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03409 | - |
dc.relation.journalcode | J02364 | - |
dc.identifier.eissn | 1872-7972 | - |
dc.identifier.pmid | 11137751 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0304394000016621 | - |
dc.subject.keyword | Hyperalgesia | - |
dc.subject.keyword | Inflammation | - |
dc.subject.keyword | Freund's complete adjuvant | - |
dc.subject.keyword | Glutamate | - |
dc.subject.keyword | MK-801 | - |
dc.subject.keyword | 6-Cyano-7-nitroqiunoxaline-2,3-dione | - |
dc.contributor.alternativeName | Leem, Joong Woo | - |
dc.contributor.affiliatedAuthor | Leem, Joong Woo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 297 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 155 | - |
dc.citation.endPage | 158 | - |
dc.identifier.bibliographicCitation | NEUROSCIENCE LETTERS, Vol.297(3) : 155-158, 2001 | - |
dc.identifier.rimsid | 31022 | - |
dc.type.rims | ART | - |
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