Cited 25 times in
Diffusion-weighted image and MR spectroscopic analysis of a case of MELAS with repeated attacks
DC Field | Value | Language |
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dc.contributor.author | 김동익 | - |
dc.contributor.author | 김현숙 | - |
dc.contributor.author | 윤평호 | - |
dc.contributor.author | 이병인 | - |
dc.contributor.author | 이종두 | - |
dc.contributor.author | 정은기 | - |
dc.date.accessioned | 2016-02-19T11:07:17Z | - |
dc.date.available | 2016-02-19T11:07:17Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/142443 | - |
dc.description.abstract | We report the clinical and MR manifestations of an 18 year-old girl with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome. Recurrent status epilepticus caused reversible cytotoxic edema on diffusion-weighted images (DWI). Initial and one month follow-up MR spectroscopy, after seizure control, showed some discrepancies in the ratio of metabolites. N-acetylaspartate (NAA) partially recovered (NAA/creatine (Cr) ratio: 1.27→1.84). This was because of a normalization of decreased NAA due to cellular dysfunction as a result of status epilepticus. A low ratio of NAA/Cr due to abnormal mitochondria remained in the decreased state. Reversible NAA/Cr ratios in the acute lesion suggested that NAA reflects the neuronal function as well as the level of neuronal structural damage. The altered NAA/Cr ratio better correlated with the abnormal signal intensity area of T2-weighted images (T2WI) and DWI than the lactate (Lac)/Cr ratio. With conservative treatment with anti-epileptics not accompanied by coenzyme Q or sodium dichloroacetate, lactate persistently increased (Lac/Cr ratio: 1.01→1.21) because of the continued production of lactate in cells with respiratory deficiency, which is the main pathology of MELAS. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 128~133 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Aspartic Acid/analogs & derivatives* | - |
dc.subject.MESH | Aspartic Acid/metabolism | - |
dc.subject.MESH | Brain/metabolism | - |
dc.subject.MESH | Creatine/metabolism | - |
dc.subject.MESH | Diffusion | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | MELAS Syndrome/diagnosis* | - |
dc.subject.MESH | MELAS Syndrome/metabolism | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Magnetic Resonance Spectroscopy | - |
dc.title | Diffusion-weighted image and MR spectroscopic analysis of a case of MELAS with repeated attacks | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학) | - |
dc.contributor.googleauthor | Hyun Sook Kim | - |
dc.contributor.googleauthor | Dong Ik Kim | - |
dc.contributor.googleauthor | Byung In Lee | - |
dc.contributor.googleauthor | Eun Kee Jeong | - |
dc.contributor.googleauthor | Chulhee Choi | - |
dc.contributor.googleauthor | Jong Doo Lee | - |
dc.contributor.googleauthor | Pyeong Ho Yoon | - |
dc.contributor.googleauthor | Eun Ju Kim | - |
dc.contributor.googleauthor | Seung Hyung Kim | - |
dc.contributor.googleauthor | Yong Kyu Yoon | - |
dc.identifier.doi | 10.3349/ymj.2001.42.1.128 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00408 | - |
dc.contributor.localId | A02616 | - |
dc.contributor.localId | A02797 | - |
dc.contributor.localId | A03138 | - |
dc.contributor.localId | A03684 | - |
dc.contributor.localId | A01119 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 11293491 | - |
dc.subject.keyword | Magnetic resonance imaging | - |
dc.subject.keyword | diffusion study | - |
dc.subject.keyword | spectroscopy | - |
dc.subject.keyword | MELAS | - |
dc.subject.keyword | brain metabolism | - |
dc.contributor.alternativeName | Kim, Dong Ik | - |
dc.contributor.alternativeName | Kim, Hyun Sook | - |
dc.contributor.alternativeName | Yoon, Pyeong Ho | - |
dc.contributor.alternativeName | Lee, Byung In | - |
dc.contributor.alternativeName | Lee, Jong Doo | - |
dc.contributor.alternativeName | Jeong, Eun Kee | - |
dc.contributor.affiliatedAuthor | Kim, Dong Ik | - |
dc.contributor.affiliatedAuthor | Yoon, Pyeong Ho | - |
dc.contributor.affiliatedAuthor | Lee, Byung In | - |
dc.contributor.affiliatedAuthor | Lee, Jong Doo | - |
dc.contributor.affiliatedAuthor | Jeong, Eun Kee | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Sook | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 42 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 128 | - |
dc.citation.endPage | 133 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.42(1) : 128-133, 2001 | - |
dc.identifier.rimsid | 31007 | - |
dc.type.rims | ART | - |
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