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흰쥐의 뇌조직에서 Protease Inhibitor Nexin - 1 과 N - Methylpurine - DNA Glycosylase 유전자 발현연구

Other Titles
 Differential Expression of the Protease Inhibitor Nexin - 1 and N - Methylpurine - DNA Glycosylase Gene in Sprague - Dawley Rat Brain 
 김남근 ; 황태선 ; 정기화 ; 고정재 ; 김병성 ; 황성규 ; 오도연 ; 안정용 ; 강원석 ; 김남일 
 Korean Journal of Genetics (한국유전학회지), Vol.23(4) : 325~331, 2001 
Journal Title
 Korean Journal of Genetics  (한국유전학회지) 
Issue Date
Protease nexin-1(PN-1) is a potent thrombin inhibitor that is identical to the glia-derived neurite promoting factor or glia-derived nexin. It also plays a role in regulating proteolytic activity of plasminogen activator(PA) system. PN-1 is known to be involved in tissue remodeling, cellular invasiveness, matrix degradation and tumor growth. The multifunctional mammalian N-methylpurine-DNA glycosylase(MPG) is responsible for the DNA repair of alkylating damages. In this study, we examined regional differences of PN-1 and MPG transcript in the adult rat brain. Results show a widespread but heterogeneous patterns of expression. These analyses revealed distinct spatial PN-1 and MPG expression patterns in thalamus, olfactory bulb, midbrain, cerebellum, hippocampus, basal ganglia, septal area, spinal cord, pons, cerebral cortex, pituitary gland and medulla oblongata. Interestingly, PN-1 and MPG expressions were found in all tested brain regions with about two-fold differences(p>0.05). The differential regulation of PN-1 and MPG expression across different regions of the rat brain suggests multiple roles in tissue homeostasis and DNA damages.
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1. 연구논문 > 1. College of Medicine > Dept. of Neurosurgery
Yonsei Authors
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