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흰쥐의 뇌조직에서 Protease Inhibitor Nexin - 1 과 N - Methylpurine - DNA Glycosylase 유전자 발현연구
DC Field | Value | Language |
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dc.contributor.author | 안정용 | - |
dc.date.accessioned | 2016-02-19T11:07:15Z | - |
dc.date.available | 2016-02-19T11:07:15Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 1976-9571 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/142442 | - |
dc.description.abstract | Protease nexin-1(PN-1) is a potent thrombin inhibitor that is identical to the glia-derived neurite promoting factor or glia-derived nexin. It also plays a role in regulating proteolytic activity of plasminogen activator(PA) system. PN-1 is known to be involved in tissue remodeling, cellular invasiveness, matrix degradation and tumor growth. The multifunctional mammalian N-methylpurine-DNA glycosylase(MPG) is responsible for the DNA repair of alkylating damages. In this study, we examined regional differences of PN-1 and MPG transcript in the adult rat brain. Results show a widespread but heterogeneous patterns of expression. These analyses revealed distinct spatial PN-1 and MPG expression patterns in thalamus, olfactory bulb, midbrain, cerebellum, hippocampus, basal ganglia, septal area, spinal cord, pons, cerebral cortex, pituitary gland and medulla oblongata. Interestingly, PN-1 and MPG expressions were found in all tested brain regions with about two-fold differences(p>0.05). The differential regulation of PN-1 and MPG expression across different regions of the rat brain suggests multiple roles in tissue homeostasis and DNA damages. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 325~331 | - |
dc.relation.isPartOf | Korean Journal of Genetics (한국유전학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 흰쥐의 뇌조직에서 Protease Inhibitor Nexin - 1 과 N - Methylpurine - DNA Glycosylase 유전자 발현연구 | - |
dc.title.alternative | Differential Expression of the Protease Inhibitor Nexin - 1 and N - Methylpurine - DNA Glycosylase Gene in Sprague - Dawley Rat Brain | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학) | - |
dc.contributor.googleauthor | 김남근 | - |
dc.contributor.googleauthor | 황태선 | - |
dc.contributor.googleauthor | 김남일 | - |
dc.contributor.googleauthor | 강원석 | - |
dc.contributor.googleauthor | 안정용 | - |
dc.contributor.googleauthor | 오도연 | - |
dc.contributor.googleauthor | 황성규 | - |
dc.contributor.googleauthor | 김병성 | - |
dc.contributor.googleauthor | 고정재 | - |
dc.contributor.googleauthor | 정기화 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02260 | - |
dc.relation.journalcode | J02017 | - |
dc.identifier.url | http://www.papersearch.net/view/detail.asp?detail_key=09001307&code=CP00000002 | - |
dc.subject.keyword | protease nexin-1(PN-1) | - |
dc.subject.keyword | MPG | - |
dc.subject.keyword | brain | - |
dc.subject.keyword | base excision repair | - |
dc.subject.keyword | rat | - |
dc.subject.keyword | mRNA | - |
dc.contributor.alternativeName | Ahn, Jung Yong | - |
dc.contributor.affiliatedAuthor | Ahn, Jung Yong | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 23 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 325 | - |
dc.citation.endPage | 331 | - |
dc.identifier.bibliographicCitation | Korean Journal of Genetics (한국유전학회지), Vol.23(4) : 325-331, 2001 | - |
dc.identifier.rimsid | 31006 | - |
dc.type.rims | ART | - |
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