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악성 흑색종과 양성 멜라닌세포성 모반에서 MART-1의 발현에 관한 연구

Other Titles
 MART-1 Expression in Malignant Melanoma and Benign Melanocytic Nevi 
 최성환 ; 이민걸 ; 김유찬 ; 신용우 ; 박향준 ; 이증훈 ; 조상호 
 Korean Journal of Dermatology (대한피부과학회지), Vol.39(8) : 878~882, 2001 
Journal Title
 Korean Journal of Dermatology (대한피부과학회지) 
Issue Date
Background: MART-1(melanoma antigen recognized by T cell) is a well-known marker for malignant melanoma. Its immunoreactivity is also expressed in other melanocytic lineage. Objective: Our purpose is to evaluate the usefulness of MART-1 in the diagnosis of malignant melanoma. Methods: MART-1 immunostaining was performed in 26 cases of malignant melanoma and 12 cases of benign melanocytic nevi. HMB-45 immunostaining was performed in 26 cases of malignant melanoma. Results: l. Eighteen of 26 melanomas(69%) and 10 of 12 benign melanocytic nevi(83%) showed reactivity with MART-1. 2. HMB-45 showed a higher sensitivity(85%) than that of MART-1 in the staining of malignant melanoma. 3. Two of 5 HMB-45-negative melanomas were immunoreactive with MART-1, and 2 of 7 MART-1-negative melanomas were reactive with HMB-45. Conclusion: MART-1 immunostaining is not helpful to differentiate malignant melanoma from benign melanocytic nevi. MART-1 was immunoreactive to some cases of HMB-45 negative malignant melanoma. MART-1, together with S-100 protein and HMB-45, is another useful marker of malignant melanoma.
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1. 연구논문 > 1. College of Medicine > Dept. of Dermatology
Yonsei Authors
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