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악성 흑색종과 양성 멜라닌세포성 모반에서 MART-1의 발현에 관한 연구
DC Field | Value | Language |
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dc.contributor.author | 이민걸 | - |
dc.date.accessioned | 2016-02-19T11:05:45Z | - |
dc.date.available | 2016-02-19T11:05:45Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0494-4739 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/142385 | - |
dc.description.abstract | Background: MART-1(melanoma antigen recognized by T cell) is a well-known marker for malignant melanoma. Its immunoreactivity is also expressed in other melanocytic lineage. Objective: Our purpose is to evaluate the usefulness of MART-1 in the diagnosis of malignant melanoma. Methods: MART-1 immunostaining was performed in 26 cases of malignant melanoma and 12 cases of benign melanocytic nevi. HMB-45 immunostaining was performed in 26 cases of malignant melanoma. Results: l. Eighteen of 26 melanomas(69%) and 10 of 12 benign melanocytic nevi(83%) showed reactivity with MART-1. 2. HMB-45 showed a higher sensitivity(85%) than that of MART-1 in the staining of malignant melanoma. 3. Two of 5 HMB-45-negative melanomas were immunoreactive with MART-1, and 2 of 7 MART-1-negative melanomas were reactive with HMB-45. Conclusion: MART-1 immunostaining is not helpful to differentiate malignant melanoma from benign melanocytic nevi. MART-1 was immunoreactive to some cases of HMB-45 negative malignant melanoma. MART-1, together with S-100 protein and HMB-45, is another useful marker of malignant melanoma. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 878~882 | - |
dc.relation.isPartOf | Korean Journal of Dermatology (대한피부과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 악성 흑색종과 양성 멜라닌세포성 모반에서 MART-1의 발현에 관한 연구 | - |
dc.title.alternative | MART-1 Expression in Malignant Melanoma and Benign Melanocytic Nevi | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학) | - |
dc.contributor.googleauthor | 최성환 | - |
dc.contributor.googleauthor | 이민걸 | - |
dc.contributor.googleauthor | 조상호 | - |
dc.contributor.googleauthor | 이증훈 | - |
dc.contributor.googleauthor | 박향준 | - |
dc.contributor.googleauthor | 신용우 | - |
dc.contributor.googleauthor | 김유찬 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02779 | - |
dc.relation.journalcode | J02000 | - |
dc.subject.keyword | MART-1 | - |
dc.subject.keyword | malignant melanoma | - |
dc.subject.keyword | benign melanocytic nevi | - |
dc.contributor.alternativeName | Lee, Min Geol | - |
dc.contributor.affiliatedAuthor | Lee, Min Geol | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 39 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 878 | - |
dc.citation.endPage | 882 | - |
dc.identifier.bibliographicCitation | Korean Journal of Dermatology (대한피부과학회지), Vol.39(8) : 878-882, 2001 | - |
dc.identifier.rimsid | 30963 | - |
dc.type.rims | ART | - |
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