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Low serum cholesterol and haemorrhagic stroke in men: Korea Medical Insurance Corporation Study

Authors
 Dr Il Suh  ;  Sun Ha Jee  ;  Hyeon Chang Kim  ;  Chung Mo Nam  ;  Il Soon Kim  ;  Lawrence J Appel 
Citation
 Lancet, Vol.357(9260) : 922-925, 2001 
Journal Title
 Lancet 
ISSN
 0140-6736 
Issue Date
2001
Abstract
BACKGROUND: In some prospective studies, haemorrhagic stroke occurs more frequently in individuals with low serum cholesterol than in those with higher concentrations. We aimed to determine whether low total serum cholesterol is an independent risk factor for haemorrhagic stroke (intracerebral haemorrhage and subarachnoid haemorrhage) in South Korea, a country that has a population with relatively low concentrations of total serum cholesterol. METHODS: We measured total serum cholesterol and other cardiovascular risk factors in 114,793 Korean men, aged between 35-59 years in 1990 and 1992, in a prospective observational study. We used data obtained in 1992 for smoking and alcohol consumption. We divided total serum cholesterol into quintiles (<4.31 mmol/L, 4.31-<4.74, 4.74-<5.16, 5.16-<5.69 and > or = 5.69). Our primary outcomes were hospital admissions and deaths from intracerebral and subarachnoid haemorrhage in a 6 year follow-up between 1993 and 1998. FINDINGS: 528 men had a haemorrhagic stroke--372 intracerebral and 98 subarachnoid haemorrhage--and 58 were unspecified strokes. The relative risks of intracerebral haemorrhage in each quintile of total serum cholesterol (lowest to highest were: 1.22 (95% CI 0.88-1.69); 0.86 (0.60-1.21); 1.08 (0.78-1.48); and 1.03 (0.75-1.41). The corresponding relative risks for subarachnoid haemorrhage were: 1.44 (0.76-2.73); 1.13 (0.59-2.20); 1.21 (0.64-2.29); and 1.12 (0.59-2.14). INTERPRETATION: Low total serum cholesterol is not an independent risk factor for either intracerebral or subarachnoid haemorrhagic stroke in Korean men.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142314
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실)
1. Journal Papers (연구논문) > 4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원)
Yonsei Authors
김현창(Kim, Hyeon Chang) ; 남정모(Nam, Jung Mo) ; 서일(Suh, Il) ; 지선하(Jee, Sun Ha)
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http://www.sciencedirect.com/science/article/pii/S0140673600042136
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