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Induction of a1-Acid Glycoprotein mRNA by Cytokines and Differentiation in Human Colon Carcinoma Cell

Authors
 Soo Young Lee  ;  Joo Weon Lim  ;  You-Mie Kim  ;  Il-Ha Lee  ;  Young-Chul Choi  ;  Kun Chun Park 
Citation
 MOLECULES AND CELLS, Vol.11(2) : 164-169, 2001 
Journal Title
 MOLECULES AND CELLS 
ISSN
 1016-8478 
Issue Date
2001
MeSH
Cell Differentiation ; Colonic Neoplasms/genetics* ; Colonic Neoplasms/pathology ; Culture Media, Serum-Free ; Gene Expression Regulation, Neoplastic* ; HT29 Cells ; HeLa Cells ; Humans ; Interleukin-1/pharmacology ; Interleukin-6/pharmacology ; Orosomucoid/biosynthesis ; Orosomucoid/genetics* ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Tumor Cells, Cultured ; Tumor Necrosis Factor-alpha/pharmacology
Keywords
a1-acid Glycoprotein (AAG) ; Acute Phase Proteins ; HT-29 Human Colon Carcinoma Cells
Abstract
The mRNA for the 1-acid glycoprotein (AAG) was expressed not only in hepatoma cells, but also in non- hepatic cancer cells. The expression of the AAG mRNA in HT-29 human colon carcinoma cells is induced by cytokines, IL-6, IL-1, and TNF-, in a manner characteristic of the acute phase response, and the expression of AAG mRNA was up-regulated in differentiated HT-29 cells.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Institute of Gastroenterology (소화기병연구소) > 1. Journal Papers
Yonsei Authors
Lim, Joo Weon(임주원)
Choi, Young Chul(최영철) ORCID logo https://orcid.org/0000-0001-5525-6861
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142302
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