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인체 코점막에서 MUC5AC와 MUC8 mRNA의 발현

Other Titles
 Expression of MUC5AC and MUC8 mRNA in human nasal mucosa 
 김현웅 ; 이용훈 ; 윤주헌 ; 이정권 
 Korean Journal of Otorhinolaryngology-Head and Neck Surgery (대한이비인후과학회지 두경부외과학), Vol.44(5) : 490~494, 2001 
Journal Title
 Korean Journal of Otorhinolaryngology-Head and Neck Surgery  (대한이비인후과학회지 두경부외과학) 
Issue Date
Background and Objectives:Sinusitis is one of the most commonly reported diseases in the world. A network of inflammatory mediators is known to be involved in the pathogenesis of chronic sinusitis and nasal mucus secretion may also be under the control of an inflammatory mediator network. To date, 12 human mucin genes have been identified;however, the regulation of MUC8 has not yet been found out. In this study, we described the regulation of the MUC8 mRNA expression by inflammatory mediators and investigated its cellular location. Materials and Method:MUC8 mRNA and MUC5AC mRNA were detected in culture using passage-2 normal human nasal epithelial (NHNE) cells after the treatment with a mixture of following inflammatory mediators;TNF-α, IL-1β, LPS, IL-4, PAF. The translocation of MUC8 mRNA from the nucleus to the cytoplasm was investigated by treating the inflammatory mediators with in situ hybridization. Results:We found that a mixture of inflammatory mediators increased the MUC8 mRNA expression but decreased the MUC5AC mRNA expression in cultured normal human nasal epithelial cells. Among the inflammatory mediators, Interleukin-4 was responsible for the decrease in the MUC5AC mRNA expression and the MUC5AC mucin secretion. We also found that MUC8 mRNA resides in the nucleus of goblet cells and is transported into the cytoplasm following the treatment with inflammatory mediators. Conclusion:These results indicate that MUC8 may play an important role in the pathogenesis of mucus hypersecretion in chronic sinusitis
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1. 연구논문 > 1. College of Medicine > Dept. of Otorhinolaryngology
Yonsei Authors
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