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사람 배자 및 태아에서 정상적으로 일어나는 창자의 회전,관강 폐쇄 및 재형성

Other Titles
 Intestinal rotation, luminal obstruction and recanalization in the human embryos and fetuses 
 박형우  ;  안대호  ;  김명희 
 Korean Journal of Physical Anthropology, Vol.14(3) : 235-248, 2001 
Journal Title
Korean Journal of Physical Anthropology(대한체질인류학회지)
Issue Date
Human ; embryo ; fetus ; primitive gut ; intestinal rotation ; physiologic umbilical hernia
The development of intestine can be characterized by the following two traits. First, at the beginning of its development, the intestine is temporarily herniated into the umbilical cord, then reduced into the abdominal cavity, and finally reaches its adult location, rotating along the way. Nevertheless, no time table is yet available as to show, in a precise manner, when the intestine is herniated, when it is reduced, or to what extent the rotation occurs. Secondly, it is known that in the course of intestinal development, the lumen is temporarily obstructed by epithelial proliferation and then undergoes the recanalization. However, it is not yet certain whether there is practically a complete luminal obstruction, even by supposing that there is a complete obstruction, no theory has yet been established to determine the time, location, or the extent of the obstruction, and the time of the recanalization.
In this study, 2-12 week old human embryos and fetuses have been used which were microdissected under a surgical microscope and were subsequently observed in an ordinary tissue slide. We have obtained the following results.
1. The intestine was first formed at Carnegie stage 5. Together with the folds of the embryos, three parts of the primitive gut were observed for the first time at stage 10. At stage 12, the primitive gut was located on the midline.
2. At stage IS, the intestine rotated to 900 counterclockwise, and at the next stage, it started herniation. There was another 900 counterclockwise rotation at stage 20, and at the beginning of the 9th week, with the rapid reduction into the abdominal cavity, the cecum was located in the proper adult position, and the rotation completed.
3. Although epithelial proliferation was recognizable in the esophagus, duodenum and other parts of the intestine of the developing embryo, we could not find any cases in which the lumen was completely obstructed.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myoung Hee(김명희) ORCID logo https://orcid.org/0000-0001-5652-1452
Park, Hyoung Woo(박형우) ORCID logo https://orcid.org/0000-0002-5341-9249
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