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Effect of low-dose irradiation on induction of an apoptotic adaptive response in the murine system

Authors
 J. Seong  ;  Sung Hee Kim  ;  Hong Ryul Pyo  ;  Eun Ji Chung  ;  Chang Ok Suh 
Citation
 RADIATION AND ENVIRONMENTAL BIOPHYSICS, Vol.40(4) : 335-339, 2001 
Journal Title
RADIATION AND ENVIRONMENTAL BIOPHYSICS
ISSN
 0301-634X 
Issue Date
2001
MeSH
Animals ; Apoptosis/radiation effects* ; Blotting, Western ; DNA Fragmentation ; Dose-Response Relationship, Radiation ; Humans ; Male ; Mice ; Mice, Inbred C3H ; Tumor Cells, Cultured
Keywords
Adaptive Response ; Murine Tumor ; Priming Dose ; Syngeneic Tumor ; Murine System
Abstract
The aim of the study was to investigate the effect of low doses of irradiation on the induction of an apoptotic adaptive response in the murine system using C3H/HeJ mice bearing 8 mm syngeneic tumors, HCa-I and OCa-I. In OCa-I, the 0.05 Gy priming dose significantly reduced the 25 Gy-induced apoptosis by 30%, whereas this reduction was not seen in HCa-I. The analysis of apoptosis-regulating molecules showed that the application of a priming dose increased the radiation- induced p53 level in both tumors. No other regulators changed in OCa-I. However, in HCa-I, the application of a priming dose increased radiation-induced Bcl-XL and Bcl-XS, but not Bcl-2 or Bax. An apoptotic adaptive response induced by low-dose radiation was shown in one murine tumor, OCa-I and Bcl-XL and Bcl-XS appeared to be implicated.
Full Text
http://link.springer.com/article/10.1007/s00411-001-0122-7
DOI
10.1007/s00411-001-0122-7
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Seong, Jin Sil(성진실) ORCID logo https://orcid.org/0000-0003-1794-5951
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142139
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