Cited 14 times in
Effect of low-dose irradiation on induction of an apoptotic adaptive response in the murine system
DC Field | Value | Language |
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dc.contributor.author | 성진실 | - |
dc.date.accessioned | 2016-02-19T10:59:14Z | - |
dc.date.available | 2016-02-19T10:59:14Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0301-634X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/142139 | - |
dc.description.abstract | The aim of the study was to investigate the effect of low doses of irradiation on the induction of an apoptotic adaptive response in the murine system using C3H/HeJ mice bearing 8 mm syngeneic tumors, HCa-I and OCa-I. In OCa-I, the 0.05 Gy priming dose significantly reduced the 25 Gy-induced apoptosis by 30%, whereas this reduction was not seen in HCa-I. The analysis of apoptosis-regulating molecules showed that the application of a priming dose increased the radiation- induced p53 level in both tumors. No other regulators changed in OCa-I. However, in HCa-I, the application of a priming dose increased radiation-induced Bcl-XL and Bcl-XS, but not Bcl-2 or Bax. An apoptotic adaptive response induced by low-dose radiation was shown in one murine tumor, OCa-I and Bcl-XL and Bcl-XS appeared to be implicated. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 335~339 | - |
dc.relation.isPartOf | RADIATION AND ENVIRONMENTAL BIOPHYSICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Apoptosis/radiation effects* | - |
dc.subject.MESH | Blotting, Western | - |
dc.subject.MESH | DNA Fragmentation | - |
dc.subject.MESH | Dose-Response Relationship, Radiation | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C3H | - |
dc.subject.MESH | Tumor Cells, Cultured | - |
dc.title | Effect of low-dose irradiation on induction of an apoptotic adaptive response in the murine system | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학) | - |
dc.contributor.googleauthor | J. Seong | - |
dc.contributor.googleauthor | Sung Hee Kim | - |
dc.contributor.googleauthor | Hong Ryul Pyo | - |
dc.contributor.googleauthor | Eun Ji Chung | - |
dc.contributor.googleauthor | Chang Ok Suh | - |
dc.identifier.doi | 10.1007/s00411-001-0122-7 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01956 | - |
dc.relation.journalcode | J02590 | - |
dc.identifier.eissn | 1432-2099 | - |
dc.identifier.pmid | 11820743 | - |
dc.identifier.url | http://link.springer.com/article/10.1007/s00411-001-0122-7 | - |
dc.subject.keyword | Adaptive Response | - |
dc.subject.keyword | Murine Tumor | - |
dc.subject.keyword | Priming Dose | - |
dc.subject.keyword | Syngeneic Tumor | - |
dc.subject.keyword | Murine System | - |
dc.contributor.alternativeName | Seong, Jin Sil | - |
dc.contributor.affiliatedAuthor | Seong, Jin Sil | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 40 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 335 | - |
dc.citation.endPage | 339 | - |
dc.identifier.bibliographicCitation | RADIATION AND ENVIRONMENTAL BIOPHYSICS, Vol.40(4) : 335-339, 2001 | - |
dc.identifier.rimsid | 31634 | - |
dc.type.rims | ART | - |
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