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Effect of low-dose irradiation on induction of an apoptotic adaptive response in the murine system

DC FieldValueLanguage
dc.contributor.author성진실-
dc.date.accessioned2016-02-19T10:59:14Z-
dc.date.available2016-02-19T10:59:14Z-
dc.date.issued2001-
dc.identifier.issn0301-634X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/142139-
dc.description.abstractThe aim of the study was to investigate the effect of low doses of irradiation on the induction of an apoptotic adaptive response in the murine system using C3H/HeJ mice bearing 8 mm syngeneic tumors, HCa-I and OCa-I. In OCa-I, the 0.05 Gy priming dose significantly reduced the 25 Gy-induced apoptosis by 30%, whereas this reduction was not seen in HCa-I. The analysis of apoptosis-regulating molecules showed that the application of a priming dose increased the radiation- induced p53 level in both tumors. No other regulators changed in OCa-I. However, in HCa-I, the application of a priming dose increased radiation-induced Bcl-XL and Bcl-XS, but not Bcl-2 or Bax. An apoptotic adaptive response induced by low-dose radiation was shown in one murine tumor, OCa-I and Bcl-XL and Bcl-XS appeared to be implicated.-
dc.description.statementOfResponsibilityopen-
dc.format.extent335~339-
dc.relation.isPartOfRADIATION AND ENVIRONMENTAL BIOPHYSICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHApoptosis/radiation effects*-
dc.subject.MESHBlotting, Western-
dc.subject.MESHDNA Fragmentation-
dc.subject.MESHDose-Response Relationship, Radiation-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C3H-
dc.subject.MESHTumor Cells, Cultured-
dc.titleEffect of low-dose irradiation on induction of an apoptotic adaptive response in the murine system-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학)-
dc.contributor.googleauthorJ. Seong-
dc.contributor.googleauthorSung Hee Kim-
dc.contributor.googleauthorHong Ryul Pyo-
dc.contributor.googleauthorEun Ji Chung-
dc.contributor.googleauthorChang Ok Suh-
dc.identifier.doi10.1007/s00411-001-0122-7-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01956-
dc.relation.journalcodeJ02590-
dc.identifier.eissn1432-2099-
dc.identifier.pmid11820743-
dc.identifier.urlhttp://link.springer.com/article/10.1007/s00411-001-0122-7-
dc.subject.keywordAdaptive Response-
dc.subject.keywordMurine Tumor-
dc.subject.keywordPriming Dose-
dc.subject.keywordSyngeneic Tumor-
dc.subject.keywordMurine System-
dc.contributor.alternativeNameSeong, Jin Sil-
dc.contributor.affiliatedAuthorSeong, Jin Sil-
dc.rights.accessRightsnot free-
dc.citation.volume40-
dc.citation.number4-
dc.citation.startPage335-
dc.citation.endPage339-
dc.identifier.bibliographicCitationRADIATION AND ENVIRONMENTAL BIOPHYSICS, Vol.40(4) : 335-339, 2001-
dc.identifier.rimsid31634-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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