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Hyperfractionated re-irradiation using a 3-dimensional conformal technique for locally recurrent carcinoma of the nasopharynx; preliminary results

Authors
 Jae Ho Cho  ;  Gwi Eon Kim  ;  Kwang Hwan Cho  ;  Chang Geol Lee  ;  Yong Bae Kim  ;  Sang Wook Lee  ;  Ki Chang Keum  ;  Chang Ok Suh 
Citation
 YONSEI MEDICAL JOURNAL, Vol.42(1) : 55-64, 2001 
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
 0513-5796 
Issue Date
2001
MeSH
Aged ; Dose Fractionation, Radiation* ; Humans ; Male ; Middle Aged ; Nasopharyngeal Neoplasms/radiotherapy* ; Neoplasm Recurrence, Local/radiotherapy* ; Radiotherapy Dosage ; Radiotherapy, Conformal*
Keywords
carcinoma of the nasopharynx ; re-irradiation ; hyperfractionation ; three-dimensional conformal radiotherapy
Abstract
To evaluate the efficacy of hyperfractionated re-irradiation using a three-dimensional conformal radiotherapy (3-D CRT) technique in patients with locally recurrent carcinoma of the nasopharynx. Four patients with locally recurrent nasopharyngeal cancer were retreated with a hyperfractionated schedule using a 3-D CRT technique. Re-irradiation was delivered in 1.1-1.2 Gy fractions twice per day (BID), with interfraction intervals of more than 6 hours. The total dose ranged from 59.4 to 69.2 Gy. A 3-D CRT technique with 5- or 6-field coplanar and/or non-coplanar beams were employed during the entire treatment procedure. All four patients achieved complete remission of locally recurrent lesions, with marked improvement of subjective symptoms, immediately after re-irradiation. All are alive and well without evidence of disease after limited follow-up periods, which range from 7 to 20 months. So far, there have been no radiation-induced neurologic complications. Four patients with locally recurrent carcinoma of the nasopharynx were successfully treated by hyperfractionated re-irradiation using a 3-D CRT technique. A relatively high re-irradiation dose of more than 60 Gy may be safely delivered with no serious acute or late radiation-induced complications in patients with local recurrences and who were initially treated with doses greater than 70 Gy.
Files in This Item:
T200101630.pdf Download
DOI
10.3349/ymj.2001.42.1.55
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Kim, Gwi Eon(김귀언)
Lee, Chang Geol(이창걸) ORCID logo https://orcid.org/0000-0002-8702-881X
Cho, Jae Ho(조재호) ORCID logo https://orcid.org/0000-0001-9966-5157
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142124
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