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인슐린 저항성과 고감도 C-반응성단백의 연관성

Other Titles
 The Relationship of Insulin Resistance to High-Sensitivity C-Reactive Protein. 
Authors
 박노진  ;  김정호  ;  윤용석  ;  송영득  ;  김경래  ;  송경순  ;  권오헌  ;  허갑범 
Citation
 Korean Journal of Clinical Pathology (대한임상병리학회지), Vol.21(6) : 465-470, 2001 
Journal Title
Korean Journal of Clinical Pathology(대한임상병리학회지)
ISSN
 1598-6535 
Issue Date
2001
Keywords
Insulin resistance ; High-sensitivity C-reactive protein ; Type 2 diabetes mellitus ; Glucose disposal rate, Inflammation
Abstract
Background
Insulin resistance is known as the common denominator of risk factors of atherosclerosis as well as the major pathogenic process of type 2 diabetes mellitus (DM). Recently some investigators indicated the relationship of chronic inflammatory reaction to atherosclerosis and insulin resistance. We examined the relationship between insulin resistance and high sensitivity CRP (hs-CRP) in Koreans.
Methods
Twenty-five patients with type 2 DM and eleven healthy men were examined. Glucose disposal rate (GDR, mg/kg/min) was determined as the index of insulin resistance by the euglycemic insulin clamp test with De Fronzo method. The serum hs-CRP level was determined by Behring nephelometric assay, fibrinogen by functional assay, and plasminogen activator inhibitor-1 (PAI-1) by ELISA. We also included 81 healthy subjects to determine the reference range of hs-CRP.
Results
The reference range (median) of hs-CRP was 0-5.20 (0.56) mg/L. The hs-CRP concentration was not significantly different between control and DM groups. The GDR of DM (3.8±1.7) showed significantly decreased value compared with normal (8.4±1.5) group (P<0.001). In all subjects, there was no significant correlation of GDR and hs-CRP.
Conclusion
There was no significant correlation of GDR and hs-CRP. We think the interventional prospective study with anti-inflammatory drug is warranted to elucidate the independent relationship between insulin resistance and hs-CRP.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jeong Ho(김정호) ORCID logo https://orcid.org/0000-0003-2479-0548
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142078
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