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인슐린 저항성과 고감도 C-반응성단백의 연관성

Other Titles
 The Relationship of Insulin Resistance to High-Sensitivity C-Reactive Protein. 
 박노진 ; 김정호 ; 허갑범 ; 권오헌 ; 송경순 ; 김경래 ; 송영득 ; 윤용석 
 Korean Journal of Clinical Pathology (대한임상병리학회지), Vol.21(6) : 465~470, 2001 
Journal Title
 Korean Journal of Clinical Pathology  (대한임상병리학회지) 
Issue Date
Background Insulin resistance is known as the common denominator of risk factors of atherosclerosis as well as the major pathogenic process of type 2 diabetes mellitus (DM). Recently some investigators indicated the relationship of chronic inflammatory reaction to atherosclerosis and insulin resistance. We examined the relationship between insulin resistance and high sensitivity CRP (hs-CRP) in Koreans. Methods Twenty-five patients with type 2 DM and eleven healthy men were examined. Glucose disposal rate (GDR, mg/kg/min) was determined as the index of insulin resistance by the euglycemic insulin clamp test with De Fronzo method. The serum hs-CRP level was determined by Behring nephelometric assay, fibrinogen by functional assay, and plasminogen activator inhibitor-1 (PAI-1) by ELISA. We also included 81 healthy subjects to determine the reference range of hs-CRP. Results The reference range (median) of hs-CRP was 0-5.20 (0.56) mg/L. The hs-CRP concentration was not significantly different between control and DM groups. The GDR of DM (3.8±1.7) showed significantly decreased value compared with normal (8.4±1.5) group (P<0.001). In all subjects, there was no significant correlation of GDR and hs-CRP. Conclusion There was no significant correlation of GDR and hs-CRP. We think the interventional prospective study with anti-inflammatory drug is warranted to elucidate the independent relationship between insulin resistance and hs-CRP.
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