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인슐린 저항성과 고감도 C-반응성단백의 연관성
DC Field | Value | Language |
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dc.contributor.author | 김정호 | - |
dc.date.accessioned | 2016-02-19T10:57:31Z | - |
dc.date.available | 2016-02-19T10:57:31Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 1598-6535 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/142078 | - |
dc.description.abstract | Background Insulin resistance is known as the common denominator of risk factors of atherosclerosis as well as the major pathogenic process of type 2 diabetes mellitus (DM). Recently some investigators indicated the relationship of chronic inflammatory reaction to atherosclerosis and insulin resistance. We examined the relationship between insulin resistance and high sensitivity CRP (hs-CRP) in Koreans. Methods Twenty-five patients with type 2 DM and eleven healthy men were examined. Glucose disposal rate (GDR, mg/kg/min) was determined as the index of insulin resistance by the euglycemic insulin clamp test with De Fronzo method. The serum hs-CRP level was determined by Behring nephelometric assay, fibrinogen by functional assay, and plasminogen activator inhibitor-1 (PAI-1) by ELISA. We also included 81 healthy subjects to determine the reference range of hs-CRP. Results The reference range (median) of hs-CRP was 0-5.20 (0.56) mg/L. The hs-CRP concentration was not significantly different between control and DM groups. The GDR of DM (3.8±1.7) showed significantly decreased value compared with normal (8.4±1.5) group (P<0.001). In all subjects, there was no significant correlation of GDR and hs-CRP. Conclusion There was no significant correlation of GDR and hs-CRP. We think the interventional prospective study with anti-inflammatory drug is warranted to elucidate the independent relationship between insulin resistance and hs-CRP. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 465~470 | - |
dc.relation.isPartOf | Korean Journal of Clinical Pathology (대한임상병리학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 인슐린 저항성과 고감도 C-반응성단백의 연관성 | - |
dc.title.alternative | The Relationship of Insulin Resistance to High-Sensitivity C-Reactive Protein. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | 박노진 | - |
dc.contributor.googleauthor | 김정호 | - |
dc.contributor.googleauthor | 윤용석 | - |
dc.contributor.googleauthor | 송영득 | - |
dc.contributor.googleauthor | 김경래 | - |
dc.contributor.googleauthor | 송경순 | - |
dc.contributor.googleauthor | 권오헌 | - |
dc.contributor.googleauthor | 허갑범 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00903 | - |
dc.relation.journalcode | J01988 | - |
dc.subject.keyword | Insulin resistance | - |
dc.subject.keyword | High-sensitivity C-reactive protein | - |
dc.subject.keyword | Type 2 diabetes mellitus | - |
dc.subject.keyword | Glucose disposal rate, Inflammation | - |
dc.contributor.alternativeName | Kim, Jeong Ho | - |
dc.contributor.affiliatedAuthor | Kim, Jeong Ho | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 21 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 465 | - |
dc.citation.endPage | 470 | - |
dc.identifier.bibliographicCitation | Korean Journal of Clinical Pathology (대한임상병리학회지), Vol.21(6) : 465-470, 2001 | - |
dc.identifier.rimsid | 31584 | - |
dc.type.rims | ART | - |
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