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Evaluation of premalignant potential in oral lichen planus using interphase cytogenetics

Authors
 Jin Kim  ;  Jong In Yook  ;  Eun Ha Lee  ;  Mi Heon Ryu  ;  Jung Hoon Yoon  ;  Jun Chul Hong  ;  Dong Ju Kim  ;  Hyun Sil Kim 
Citation
 JOURNAL OF ORAL PATHOLOGY & MEDICINE, Vol.30(2) : 65-72, 2001 
Journal Title
 JOURNAL OF ORAL PATHOLOGY & MEDICINE 
ISSN
 0904-2512 
Issue Date
2001
MeSH
Adult ; Aneuploidy ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/pathology ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/pathology ; Chromosomes, Human, Pair 17/genetics ; Chromosomes, Human, Pair 9/genetics ; Cytogenetics ; Disease Progression ; Epithelial Cells/pathology ; Female ; Humans ; In Situ Hybridization ; Interphase/genetics* ; Lichen Planus, Oral/genetics* ; Lichen Planus, Oral/pathology ; Lichenoid Eruptions/genetics ; Lichenoid Eruptions/pathology ; Lymphocytes/pathology ; Male ; Middle Aged ; Monosomy/genetics ; Mouth Diseases/genetics ; Mouth Diseases/pathology ; Mouth Mucosa/pathology ; Mouth Neoplasms/genetics* ; Mouth Neoplasms/pathology ; Precancerous Conditions/genetics* ; Precancerous Conditions/pathology
Keywords
chromosome in situ hybridization(CISH) ; genetic instability ; lichenoid dysplasia ; oral lichen planus ; premalignancy
Abstract
This study attempted to evaluate whether oral lichen planus (OLP) has the potential to progress to oral squamous cell carcinoma (OSCC) by comparing the degree of genetic instability between clinically-curable OLP and lesions that progressed to OSCC. Fifteen cases of steroid-responsive OLP and two cases of lichenoid dysplasia (LD) that progressed to OSCC were used for this study. Chromosome in situ hybridization (CISH) was performed for chromosomes 9 and 17. The fraction of polysomic and monosomic cells for chromosome 9 increased in mucosal epithelium compared to those of lymphocytes in OLP. This difference was statistically significant (P=0.0017, 0.0054, respectively). Two LD patients showed 15.38% and 22.58% of PI for chromosome 9. In OSCC that developed from LD, the fraction of monosomic cells for chromosome 9 increased by more than 70%. We concluded that LD should be treated as a high-risk premalignant lesion and strongly suggest that the monosomy of chromosome 9 may have a critical role in progress to malignancy from LD.
Full Text
http://onlinelibrary.wiley.com/doi/10.1034/j.1600-0714.2001.300201.x/abstract
DOI
10.1034/j.1600-0714.2001.300201.x
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin(김진)
Kim, Hyun Sil(김현실) ORCID logo https://orcid.org/0000-0003-3614-1764
Yook, Jong In(육종인) ORCID logo https://orcid.org/0000-0002-7318-6112
Yoon, Jung Hoon(윤정훈)
Lee, Eun Ha(이은하)
Hong, Jun Chul(홍준철)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141992
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