Cited 36 times in
Evaluation of premalignant potential in oral lichen planus using interphase cytogenetics
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김현실 | - |
dc.contributor.author | 육종인 | - |
dc.contributor.author | 윤정훈 | - |
dc.contributor.author | 이은하 | - |
dc.contributor.author | 홍준철 | - |
dc.contributor.author | 김진 | - |
dc.date.accessioned | 2016-02-19T10:55:12Z | - |
dc.date.available | 2016-02-19T10:55:12Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0904-2512 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/141992 | - |
dc.description.abstract | This study attempted to evaluate whether oral lichen planus (OLP) has the potential to progress to oral squamous cell carcinoma (OSCC) by comparing the degree of genetic instability between clinically-curable OLP and lesions that progressed to OSCC. Fifteen cases of steroid-responsive OLP and two cases of lichenoid dysplasia (LD) that progressed to OSCC were used for this study. Chromosome in situ hybridization (CISH) was performed for chromosomes 9 and 17. The fraction of polysomic and monosomic cells for chromosome 9 increased in mucosal epithelium compared to those of lymphocytes in OLP. This difference was statistically significant (P=0.0017, 0.0054, respectively). Two LD patients showed 15.38% and 22.58% of PI for chromosome 9. In OSCC that developed from LD, the fraction of monosomic cells for chromosome 9 increased by more than 70%. We concluded that LD should be treated as a high-risk premalignant lesion and strongly suggest that the monosomy of chromosome 9 may have a critical role in progress to malignancy from LD. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 65~72 | - |
dc.relation.isPartOf | JOURNAL OF ORAL PATHOLOGY & MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aneuploidy | - |
dc.subject.MESH | Carcinoma, Squamous Cell/genetics | - |
dc.subject.MESH | Carcinoma, Squamous Cell/pathology | - |
dc.subject.MESH | Cell Transformation, Neoplastic/genetics | - |
dc.subject.MESH | Cell Transformation, Neoplastic/pathology | - |
dc.subject.MESH | Chromosomes, Human, Pair 17/genetics | - |
dc.subject.MESH | Chromosomes, Human, Pair 9/genetics | - |
dc.subject.MESH | Cytogenetics | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Epithelial Cells/pathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | In Situ Hybridization | - |
dc.subject.MESH | Interphase/genetics* | - |
dc.subject.MESH | Lichen Planus, Oral/genetics* | - |
dc.subject.MESH | Lichen Planus, Oral/pathology | - |
dc.subject.MESH | Lichenoid Eruptions/genetics | - |
dc.subject.MESH | Lichenoid Eruptions/pathology | - |
dc.subject.MESH | Lymphocytes/pathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Monosomy/genetics | - |
dc.subject.MESH | Mouth Diseases/genetics | - |
dc.subject.MESH | Mouth Diseases/pathology | - |
dc.subject.MESH | Mouth Mucosa/pathology | - |
dc.subject.MESH | Mouth Neoplasms/genetics* | - |
dc.subject.MESH | Mouth Neoplasms/pathology | - |
dc.subject.MESH | Precancerous Conditions/genetics* | - |
dc.subject.MESH | Precancerous Conditions/pathology | - |
dc.title | Evaluation of premalignant potential in oral lichen planus using interphase cytogenetics | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Pathology (구강병리학) | - |
dc.contributor.googleauthor | Jin Kim | - |
dc.contributor.googleauthor | Jong In Yook | - |
dc.contributor.googleauthor | Eun Ha Lee | - |
dc.contributor.googleauthor | Mi Heon Ryu | - |
dc.contributor.googleauthor | Jung Hoon Yoon | - |
dc.contributor.googleauthor | Jun Chul Hong | - |
dc.contributor.googleauthor | Dong Ju Kim | - |
dc.contributor.googleauthor | Hyun Sil Kim | - |
dc.identifier.doi | 10.1034/j.1600-0714.2001.300201.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01121 | - |
dc.contributor.localId | A02536 | - |
dc.contributor.localId | A02599 | - |
dc.contributor.localId | A03051 | - |
dc.contributor.localId | A04828 | - |
dc.contributor.localId | A01009 | - |
dc.relation.journalcode | J01665 | - |
dc.identifier.eissn | 1600-0714 | - |
dc.identifier.pmid | 11168849 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1034/j.1600-0714.2001.300201.x/abstract | - |
dc.subject.keyword | chromosome in situ hybridization(CISH) | - |
dc.subject.keyword | genetic instability | - |
dc.subject.keyword | lichenoid dysplasia | - |
dc.subject.keyword | oral lichen planus | - |
dc.subject.keyword | premalignancy | - |
dc.contributor.alternativeName | Kim, Hyun Sil | - |
dc.contributor.alternativeName | Yook, Jong In | - |
dc.contributor.alternativeName | Yoon, Jung Hoon | - |
dc.contributor.alternativeName | Lee, Eun Ha | - |
dc.contributor.alternativeName | Hong, Jun Chul | - |
dc.contributor.alternativeName | Kim, Jin | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Sil | - |
dc.contributor.affiliatedAuthor | Yook, Jong In | - |
dc.contributor.affiliatedAuthor | Yoon, Jung Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Eun Ha | - |
dc.contributor.affiliatedAuthor | Hong, Jun Chul | - |
dc.contributor.affiliatedAuthor | Kim, Jin | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 30 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 65 | - |
dc.citation.endPage | 72 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ORAL PATHOLOGY & MEDICINE, Vol.30(2) : 65-72, 2001 | - |
dc.identifier.rimsid | 35911 | - |
dc.type.rims | ART | - |
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