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Results of a Phase II Study to Evaluate the Efficacy of Docetaxel and Carboplatin in Metastatic Malignant Melanoma Patients Who Failed First-Line Therapy Containing Dacarbazine

 Choong-kun Lee  ;  Minkyu Jung  ;  Sang Joon Shin  ;  Sun Young Rha  ;  Su Jin Heo  ;  Hyun Cheol Chung  ;  Joong Bae Ahn  ;  Mi Ryung Roh  ;  Hyo Song Kim  ;  Hye Ryun Kim  ;  Hye Jin Choi 
 Cancer Research and Treatment, Vol.47(4) : 781-789, 2015 
Journal Title
 Cancer Research and Treatment 
Issue Date
PURPOSE: There is no standard second-line regimen for malignant melanoma patients with disease progression after first-line chemotherapy, and platinum-alkylating agents combined with paclitaxel have shown modest efficacy. MATERIALS AND METHODS: We conducted a phase II, open-label, single-arm study to test the efficacy of docetaxel combined with carboplatin for malignant melanoma patients who failed previous treatment with dacarbazine. Intravenous docetaxel (35 mg/m(2) on days 1 and 8 of each cycle) and carboplatin (area under the curve 3 on days 1 and 8 of each cycle) was administered every 21 days. Primary end point was objective response rate (ORR). RESULTS: Thirty patients were enrolled in the study, and the median follow-up duration was 19.8 months. Among 25 per-protocol patients, there were three responders (1 with complete response and 2 with partial response) and 17 stable disease patients (ORR, 12.0%). Among the per-protocol population, the median progression-free survival (PFS) was 4.3 months and the median overall survival (OS) was 9.6 months. Uveal melanoma patients (n=9) showed the best prognosis compared to other subtypes (median PFS, 7.6 months; OS, 9.9 months). The most common grade 3 or 4 adverse event was neutropenia (n=15, 50.0%). CONCLUSION: Docetaxel combined with carboplatin showed association with an acceptable safety profile and overall efficacy for patients with malignant melanoma who had progressed on chemotherapy containing dacarbazine.
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실)
Yonsei Authors
김혜련(Kim, Hye Ryun) ; 김효송(Kim, Hyo Song) ; 노미령(Roh, Mi Ryung) ; 라선영(Rha, Sun Young) ; 신상준(Shin, Sang Joon) ; 안중배(Ahn, Joong Bae) ; 이충근(Lee, Choong Kun) ; 정민규(Jung, Min Kyu) ; 정현철(Chung, Hyun Cheol) ; 최혜진(Choi, Hye Jin) ; 허수진(Heo, Su Jin)
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