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Serum Reactivity Against Herpes Simplex Virus Type 1 UL48 Protein in Behçet's Disease Patients and a Behçet's Disease-like Mouse Model

 Zhenlong Zheng  ;  Seonghyang Sohn  ;  Keun Jae Ahn  ;  Dongsik Bang  ;  Sung Bin Cho 
 Acta Dermato-Venereologica, Vol.95(8) : 952-958, 2015 
Journal Title
 Acta Dermato-Venereologica 
Issue Date
Herpes simplex virus (HSV) infection is a possible pathogenic factor in Behçet's disease (BD). Using proteomics analysis, this study detected a target HSV protein. Serum IgA and IgG reactivities against the identified protein were evaluated in patients with BD and in BD-like mice. A total of 4 protein bands generated by immunoprecipitation were analysed by proteomics, and HSV UL48 was commonly found in both IgA- and IgG-reactive protein bands. Compared with controls, patients with BD and BD-like mice exhibited higher titres of IgA reacting with recombinant HSV UL48 protein. Further proteomics analysis revealed that human heat shock cognate 71 kDa protein (Hsc71) is a cross-reacting target antigen against anti-HSV UL48 antibody. In addition, our data demonstrated a very strong association between serum IgG reactivity against recombinant human Hsc71 and recombinant HSV UL48 in patients with BD. We suggest that HSV infection and impaired human Hsc71 activity may be associated with the activation of autoreactive lymphocytes.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실)
Yonsei Authors
방동식(Bang, Dong Sik)
조성빈(Cho, Sung Bin)
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