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Serum Reactivity Against Herpes Simplex Virus Type 1 UL48 Protein in Behçet's Disease Patients and a Behçet's Disease-like Mouse Model

 Zhenlong Zheng  ;  Seonghyang Sohn  ;  Keun Jae Ahn  ;  Dongsik Bang  ;  Sung Bin Cho 
 ACTA DERMATO-VENEREOLOGICA, Vol.95(8) : 952-958, 2015 
Journal Title
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Adult ; Animals ; Behcet Syndrome/blood* ; Case-Control Studies ; Cross Reactions ; Disease Models, Animal ; Endothelial Cells/immunology ; Female ; HSC70 Heat-Shock Proteins/immunology* ; Herpesvirus 1, Human/immunology* ; Humans ; Immunoglobulin A/blood* ; Immunoglobulin G/blood* ; Male ; Mice ; Mice, Inbred ICR ; Microvessels/immunology ; Middle Aged ; Recombinant Proteins/immunology ; Viral Proteins/immunology* ; Young Adult
Behçet’s disease ; herpes simplex virus ; UL48 ; Behçet’s disease-like mouse model ; proteomics ; heat shock cognate 71 kDa protein
Herpes simplex virus (HSV) infection is a possible pathogenic factor in Behçet's disease (BD). Using proteomics analysis, this study detected a target HSV protein. Serum IgA and IgG reactivities against the identified protein were evaluated in patients with BD and in BD-like mice. A total of 4 protein bands generated by immunoprecipitation were analysed by proteomics, and HSV UL48 was commonly found in both IgA- and IgG-reactive protein bands. Compared with controls, patients with BD and BD-like mice exhibited higher titres of IgA reacting with recombinant HSV UL48 protein. Further proteomics analysis revealed that human heat shock cognate 71 kDa protein (Hsc71) is a cross-reacting target antigen against anti-HSV UL48 antibody. In addition, our data demonstrated a very strong association between serum IgG reactivity against recombinant human Hsc71 and recombinant HSV UL48 in patients with BD. We suggest that HSV infection and impaired human Hsc71 activity may be associated with the activation of autoreactive lymphocytes.
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1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Bang, Dong Sik(방동식)
Cho, Sung Bin(조성빈)
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